Predominance of Abdominal Visceral Adipose Tissue Reflects the Presence of Aortic Valve Calcification

BioMed Research International
Masayoshi OikawaYasuchika Takeishi

Abstract

Background. Aortic valve calcification (AVC) is a common feature of aging and is related to coronary artery disease. Although abdominal visceral adipose tissue (VAT) plays fundamental roles in coronary artery disease, the relationship between abdominal VAT and AVC is not fully understood. Methods. We investigated 259 patients who underwent cardiac and abdominal computed tomography (CT). AVC was defined as calcified lesion on the aortic valve by CT. %abdominal VAT was calculated as abdominal VAT area/total adipose tissue area. Results. AVC was detected in 75 patients, and these patients showed higher %abdominal VAT (44% versus 38%, p < 0.05) compared to those without AVC. When the cutoff value of %abdominal VAT was set at 40.9%, the area under the curve to diagnose AVC was 0.626. Multivariable logistic regression analysis showed that age (OR 1.120, 95% CI 1.078-1.168, p < 0.01), diabetes (OR 2.587, 95% CI 1.323-5.130, p < 0.01), and %abdominal VAT (OR 1.032, 95% CI 1.003-1.065, p < 0.05) were independent risk factors for AVC. The net reclassification improvement value for detecting AVC was increased when %abdominal VAT was added to the model: 0.5093 (95% CI 0.2489-0.7697, p < 0.01). Conclusion. We determined that predominance of...Continue Reading

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Citations

Feb 16, 2018·Asian Cardiovascular & Thoracic Annals·Maryam NabatiMozhdeh Dabirian
Apr 22, 2020·The International Journal of Cardiovascular Imaging·Mehmet MustuZafer Buyukterzi
Sep 24, 2020·International Urology and Nephrology·Petrini PlytzanopoulouEvangelos Papachristou
Sep 27, 2020·Aging Clinical and Experimental Research·Maddalena ConteValentina Parisi

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