Abstract
Out of a total of 311 Mycobacterium tuberculosis isolates from sputum specimens subjected to first- and second-line drug-susceptibility testing (DST) at a hospital serving as a referral center for chronic tuberculosis (TB) cases in New Delhi, 232/311 (74.6%) isolates were found to be resistant to isoniazid and rifampicin. Among multidrug-resistant (MDR) isolates, 119/232 (51.3%) were resistant to four first-line drugs (streptomycin, isoniazid, rifampicin and ethambutol). Mono-resistance to isoniazid was observed in 18 (5.7%) isolates, while none of the isolates tested showed mono-resistance to rifampicin. 50/232 (21.5%) isolates met the definition of extensively drug resistant (XDR) TB, i.e., additional resistance to a fluoroquinolone and at least one of the three injectable second-line drugs: kanamycin, capreomycin, or amikacin. Spoligotyping of the XDR-TB isolates revealed 14 patterns; 39/50 (78%) isolates being grouped in three clusters vs. 11/50 (22%) isolates being unique. SIT1/Beijing represented the largest cluster (n=21, 42%), followed by SIT26/CAS1-Delhi (n=10, 20%) and SIT 53/T1 (n=8 isolates; 16%). This study corroborates recent observations from North India suggesting that both Beijing and CAS1-Delhi lineages consti...Continue Reading
References
Apr 1, 1997·Journal of Clinical Microbiology·J KamerbeekJ van Embden
Jul 27, 2002·Emerging Infectious Diseases·Judith R GlynnDick van Soolingen
Oct 3, 2002·Tuberculosis·N Vijaya BhanuP Seth
Jun 23, 2004·Emerging Infectious Diseases·Urvashi Balbir SinghPradeep Seth
Mar 1, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Deepak AlmeidaAjita Mehta
Mar 8, 2006·BMC Microbiology·Karine BrudeyChristophe Sola
Apr 20, 2006·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Naga SureshJitendra Nath Pande
Nov 1, 2006·Emerging Infectious Diseases·M Cristina GutierrezPhilip Supply
Dec 20, 2007·AIDS·Sarman SinghKrishnamoorthy Gopinath
May 26, 2009·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Jyoti AroraJitendra Nath Pande
Jul 1, 2009·BMC Public Health·Desiree T B D'souzaRobert J Wilkinson
Oct 16, 2009·Transactions of the Royal Society of Tropical Medicine and Hygiene·Nilanjan ChakrabortyShubhashish Kamal Guha
Jan 18, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Sankalp PurwarDevendra Singh Chauhan
Feb 4, 2011·Journal of Clinical Microbiology·Kanchan AjbaniAjita Mehta
Feb 24, 2011·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Jaya Ruth AsirvathamGeeta Chacko
Sep 7, 2011·Memórias do Instituto Oswaldo Cruz·Mandira Varma-BasilMridula Bose
Nov 15, 2011·Diagnostic Microbiology and Infectious Disease·Jee-Hyun YoonYoung-Tae Ro
Feb 11, 2012·Tuberculosis·Viral VadwaiCamilla Rodrigues
Mar 1, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Christophe DemayNalin Rastogi
Citations
Apr 30, 2011·BMC Infectious Diseases·Edgar AbadiaChristophe Sola
Oct 19, 2012·PloS One·Ouafae LahlouRajae El Aouad
Jun 1, 2016·The Indian Journal of Medical Research·Parul SinghalAmita Jain
Jun 10, 2014·PloS One·Jie LiuKanglin Wan
Feb 10, 2011·PloS One·Linus SandegrenGunilla Källenius
Jul 19, 2012·PloS One·Yih-Yuan ChenHorng-Yunn Dou
Sep 22, 2011·PloS One·Lukas FennerSebastien Gagneux
Dec 8, 2017·PloS One·Surabhi LavaniaJaya Sivaswami Tyagi
Feb 12, 2017·Journal of Epidemiology and Global Health·Jyoti AroraVithal Prasad Myneedu
Oct 17, 2019·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Husain PoonawalaSharon J Peacock
Aug 10, 2021·Frontiers in Public Health·Prince AsareDorothy Yeboah-Manu
Sep 2, 2021·New Microbes and New Infections·M Keikha, M Majidzadeh