Predominance of dfrG as determinant of trimethoprim resistance in imported Staphylococcus aureus

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
D NurjadiP Zanger

Abstract

To investigate the global occurrence of trimethoprim-sulfamethoxazole resistance and the genetic mechanisms of trimethoprim resistance, we analysed Staphylococcus aureus from travel-associated skin and soft-tissue infections treated at 13 travel clinics in Europe. Thirty-eight per cent (75/196) were trimethoprim-resistant and 21% (41/196) were resistant to trimethoprim-sulfamethoxazole. Among methicillin-resistant S. aureus, these proportions were 30% (7/23) and 17% (4/23), respectively. DfrG explained 92% (69/75) of all trimethoprim resistance in S. aureus. Travel to South Asia was associated with the highest risk of acquiring trimethoprim-sulfamethoxazole-resistant S. aureus. We conclude that globally dfrG is the predominant determinant of trimethoprim resistance in human S. aureus infection.

References

Feb 7, 2001·The Journal of Antimicrobial Chemotherapy·F J SchmitzUNKNOWN European SENTRY Participants
Aug 22, 2001·Molecular and Cellular Probes·L K NgM Mulvey
Mar 15, 2008·The Journal of Antimicrobial Chemotherapy·Dilip NathwaniUNKNOWN British Society for Antimicrobial Chemotherapy Working Party on Community-onset MRSA Infections
Jun 6, 2009·Future Microbiology·Slade O Jensen, Bruce R Lyon
Aug 3, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S BreurecF Laurent
Nov 23, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Philipp ZangerBerit Schulte
Jun 21, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dennis L StevensJames C Wade
Jun 29, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dennis L Stevens Infectious Diseases Society of America
Nov 5, 2014·Frontiers in Microbiology·Nadim CassirPhilippe Brouqui
Mar 11, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·D NurjadiP Zanger

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Citations

Apr 23, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P PhakuF Schaumburg
Apr 19, 2017·FEMS Microbiology Reviews·Timothy J Foster
Jun 27, 2019·The Journal of Antimicrobial Chemotherapy·Jinhu HuangLiping Wang
Dec 29, 2017·The New England Journal of Medicine·Daniel K YeohAsha C Bowen
Feb 6, 2017·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C CoelhoM Aires-de-Sousa
Jan 21, 2021·Tropical Medicine and Infectious Disease·Hamid BokharyGrant A Hill-Cawthorne
Apr 5, 2021·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Ioana D OlaruKatharina Kranzer
Mar 23, 2019·Microbiology Spectrum·Martin VestergaardHanne Ingmer
Jul 4, 2020·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J FriesenR Ignatius

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