PMID: 9557687Apr 29, 1998Paper

Predominance of HLA-restricted cytotoxic T-lymphocyte responses to serotype-cross-reactive epitopes on nonstructural proteins following natural secondary dengue virus infection

Journal of Virology
A MathewA L Rothman

Abstract

We examined the memory cytotoxic T-lymphocytic (CTL) responses of peripheral blood mononuclear cells (PBMC) obtained from patients in Thailand 12 months after natural symptomatic secondary dengue virus infection. In all four patients analyzed, CTLs were detected in bulk culture PBMC against nonstructural dengue virus proteins. Numerous CD4+ and CD8+ CTL lines were generated from the bulk cultures of two patients, KPP94-037 and KPP94-024, which were specific for NS1.2a (NS1 and NS2a collectively) and NS3 proteins, respectively. All CTL lines derived from both patients were cross-reactive with other serotypes of dengue virus. The CD8+ NS1.2a-specific lines from patient KPP94-037 were HLA B57 restricted, and the CD8+ NS3-specific lines from patient KPP94-024 were HLA B7 restricted. The CD4+ CTL lines from patient KPP94-037 were HLA DR7 restricted. A majority of the CD8+ CTLs isolated from patient KPP94-024 were found to recognize amino acids 221 to 232 on NS3. These results demonstrate that in Thai patients after symptomatic secondary natural dengue infections, CTLs are mainly directed against nonstructural proteins and are broadly cross-reactive.

References

Dec 1, 1989·Journal of Virology·J F BukowskiF A Ennis
Oct 1, 1994·The Journal of Experimental Medicine·L D Barber, P Parham
Apr 1, 1997·Human Immunology·D ChandanayingyongE Rungruang
Aug 1, 1997·The Journal of Infectious Diseases·S KalayanaroojF A Ennis

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Citations

May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Iva ZivnaAlan L Rothman
Jul 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Robin ParsonsJonathan L Bramson
May 10, 2012·Immunologic Research·Sarah Pagni, Ana Fernandez-Sesma
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·L J HoJ H Lai
Nov 30, 2004·Expert Review of Anti-infective Therapy·María G GuzmánGustavo Kourí
Jan 31, 2006·Cellular Microbiology·Kathleen R PageYukari C Manabe
Jan 11, 2011·The Journal of Infectious Diseases·Heidi L SmithSharone Green
Jun 12, 2010·Immunological Reviews·Raymond M WelshLiisa K Selin
Feb 27, 2016·F1000Research·Scott B Halstead
Feb 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hema S BashyamAlan L Rothman
Oct 13, 2007·Viral Immunology·Sook-San WongSazaly Abubakar
Sep 15, 2010·Proceedings of the National Academy of Sciences of the United States of America·Thaneeya DuangchindaGavin Screaton
Apr 14, 2012·Tropical Medicine and Health·Ichiro KuraneFrancis A Ennis
Oct 16, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zu T ShenLawrence J Stern
Nov 26, 2015·Nature Reviews. Immunology·Gavin ScreatonCatherine Roberts
Mar 1, 2013·Asia-Pacific Journal of Ophthalmology·Yan Tong Koh, Srinivasan Sanjay
Dec 23, 2016·Frontiers in Immunology·Yuan TianDaniela Weiskopf
Jul 24, 2018·Journal of Biomolecular Structure & Dynamics·Soudabeh SabetianYounes Ghasemi
Jun 22, 2000·The Journal of General Virology·K RaviprakashC G Hayes
Oct 17, 2013·PLoS Neglected Tropical Diseases·Eduardo J M NascimentoErnesto T A Marques
Jun 23, 2006·Reviews in Medical Virology·Joshua FinkSubhash G Vasudevan
Jul 13, 2006·FEMS Immunology and Medical Microbiology·Umeshc ChaturvediRicha Shrivastava
Nov 12, 2013·Journal of Leukocyte Biology·Shalini Sharma, Paul G Thomas
Apr 28, 2010·Immunology and Cell Biology·Heather FribergAnuja Mathew
Jul 22, 2015·Proceedings of the National Academy of Sciences of the United States of America·Daniela WeiskopfAlessandro Sette
Dec 5, 2012·PloS One·Gathsaurie Neelika MalavigeGraham S Ogg

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