PMID: 8589041Nov 1, 1995Paper

Predominance of normal karyotype in colorectal tumors from hereditary non-polyposis colorectal cancer patients

Genes, Chromosomes & Cancer
M MulerisB Dutrillaux

Abstract

We report the cytogenetic study of 9 colorectal tumors arising in patients with hereditary non-polyposis colorectal cancer (HNPCC). According to the cytogenetic classification of colorectal tumors previously proposed by us, 2 cases were of the trisomic type, 2 were of the monosomic type, and 5 had a normal karyotype. This represents a significant excess of tumors with normal karyotype in HNPCC tumors (56%) compared to sporadic cases (10/184 = 5%).

References

May 1, 1991·Diseases of the Colon and Rectum·H F VasenH T Lynch
Jun 1, 1990·Cancer Genetics and Cytogenetics·M MulerisB Dutrillaux
Dec 1, 1987·Cancer Genetics and Cytogenetics·M MulerisB Dutrillaux
Jun 15, 1982·International Journal of Cancer. Journal International Du Cancer·A ReichmannP Martin
Feb 1, 1995·Genes, Chromosomes & Cancer·G BardiS Heim
Mar 18, 1994·Science·N PapadopoulosM D Adams
May 7, 1993·Science·L A AaltonenS R Hamilton
May 7, 1993·Science·S N ThibodeauD Schaid

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Citations

Jun 11, 1999·The American Journal of Pathology·K R Loeb, L A Loeb
Mar 14, 2002·Cancer Genetics and Cytogenetics·Laurence PibouinGérard Goubin
Jan 1, 1997·Cancer Genetics and Cytogenetics·Y RemvikosB Dutrillaux
May 21, 2003·Breast Cancer Research and Treatment·Donna G Albertson
Sep 3, 2003·Nature Reviews. Cancer·Oliver M SieberIan P M Tomlinson
Aug 2, 2005·Nature Reviews. Cancer·Oliver M SieberIan P M Tomlinson
May 17, 2008·Cancer Research·Walter BodmerRobert A Beckman
Feb 4, 2010·PloS One·Hassan AshktorabHassan Brim
Oct 1, 2014·International Journal of Molecular Sciences·Rola H AliFahd Al-Mulla
Aug 19, 2003·Nature Genetics·Donna G AlbertsonJoe W Gray
Jul 11, 2003·Oncogene·Antoine M SnijdersDonna G Albertson

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