Predominant interferon-γ-mediated expression of CXCL9, CXCL10, and CCL5 proteins in the brain during chronic infection with Toxoplasma gondii in BALB/c mice resistant to development of toxoplasmic encephalitis.

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
Xiangshu WenYasuhiro Suzuki

Abstract

We examined the role of interferon-γ (IFN-γ) in expression of chemokine mRNA and proteins in the brain during chronic infection with Toxoplasma gondii using BALB/c and BALB/c-background IFN-γ knockout (IFN-γ(-/-)) mice. BALB/c mice are genetically resistant to development of toxoplasmic encephalitis and establish a latent, chronic infection in the brain through IFN-γ-mediated immune responses. Amounts of mRNA for CXCL9/MIG, CXCL10/IP-10, CXCL11/I-TAC, CCL2/MCP-1, CCL3/MIP-1α, and CCL5/RANTES significantly increased in the brains of wild-type mice after infection. CXCL9/MIG, CXCL10/IP-10, and CCL5/RANTES mRNA were most abundant among these chemokines. An increase in amounts of mRNA for CXCL10/IP-10, CCL2/MCP-1, CCL3/MIP-1α, and CCL5/RANTES was also observed in the brains of IFN-γ(-/-) mice after infection, although CXCL10/I-10 and CCL5/RANTES mRNA levels in infected IFN-γ(-/-) mice were significantly lower than those of infected wild-type animals. Amounts of mRNA for CXCL9/MIG and CXCL11/I-TAC remained at the basal levels in infected IFN-γ(-/-) mice. When amounts of the chemokine proteins were examined in the brain homogenates of uninfected and infected mice of both strains, large amounts of CXCL9/MIG, CXCL10/IP-10, and CCL5/RAN...Continue Reading

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Citations

Oct 19, 2011·Expert Reviews in Molecular Medicine·Yasuhiro SuzukiEri Ochiai
Feb 5, 2013·Journal of Neuroinflammation·Marbel TorresIsabelle Dimier-Poisson
Feb 22, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Rachel E Kneeland, S Hossein Fatemi
Jan 22, 2015·Scientific Reports·Maki NishimuraYoshifumi Nishikawa
Jun 27, 2014·Scandinavian Journal of Immunology·M PanarinaR Uibo
Nov 12, 2016·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Jordan WarfordAlexander S Easton
Jun 21, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qila SaYasuhiro Suzuki
Mar 4, 2017·Molecular Genetics and Genomics : MGG·Ekaterina V MedvedevaLyudmila V Dergunova
Jul 18, 2018·Journal of Neuroinflammation·Joshua S StoolmanBenjamin M Segal
Jul 2, 2020·The Journal of Clinical Investigation·Xiao-Yu Zhao, Sarah E Ewald
May 28, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joanna E KlementowiczQizhi Tang
Nov 27, 2020·Clinical Microbiology Reviews·Hany M ElsheikhaXing-Quan Zhu
Mar 27, 2021·Frontiers in Immunology·Maguy HamieHiba El Hajj
Jul 16, 2021·Frontiers in Immunology·Maguy HamieHiba El Hajj
Jun 13, 2014·Journal of Neuroinflammation·Deidre JanssonMike Dragunow

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