Abstract
We examined the role of interferon-γ (IFN-γ) in expression of chemokine mRNA and proteins in the brain during chronic infection with Toxoplasma gondii using BALB/c and BALB/c-background IFN-γ knockout (IFN-γ(-/-)) mice. BALB/c mice are genetically resistant to development of toxoplasmic encephalitis and establish a latent, chronic infection in the brain through IFN-γ-mediated immune responses. Amounts of mRNA for CXCL9/MIG, CXCL10/IP-10, CXCL11/I-TAC, CCL2/MCP-1, CCL3/MIP-1α, and CCL5/RANTES significantly increased in the brains of wild-type mice after infection. CXCL9/MIG, CXCL10/IP-10, and CCL5/RANTES mRNA were most abundant among these chemokines. An increase in amounts of mRNA for CXCL10/IP-10, CCL2/MCP-1, CCL3/MIP-1α, and CCL5/RANTES was also observed in the brains of IFN-γ(-/-) mice after infection, although CXCL10/I-10 and CCL5/RANTES mRNA levels in infected IFN-γ(-/-) mice were significantly lower than those of infected wild-type animals. Amounts of mRNA for CXCL9/MIG and CXCL11/I-TAC remained at the basal levels in infected IFN-γ(-/-) mice. When amounts of the chemokine proteins were examined in the brain homogenates of uninfected and infected mice of both strains, large amounts of CXCL9/MIG, CXCL10/IP-10, and CCL5/RAN...Continue Reading
References
Apr 22, 1988·Science·Y SuzukiJ S Remington
Jun 1, 1993·Infection and Immunity·Y SuzukiJ S Remington
May 1, 1993·Clinical Immunology and Immunopathology·C C ChaoP K Peterson
Dec 1, 1996·Journal of Neuroimmunology·D A BarnesH D Perez
Apr 7, 1997·The Journal of Experimental Medicine·T M Scharton-KerstenA Sher
Jun 1, 1997·Journal of Clinical Microbiology·D K HoweL D Sibley
Apr 29, 1998·Nature·M Baggiolini
Oct 10, 1998·Clinical Microbiology Reviews·E Y Denkers, R T Gazzinelli
Jun 8, 2000·Immunity·I A KhanA D Luster
Aug 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M T LiuT E Lane
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M T LiuT E Lane
Mar 29, 2001·Nature Immunology·B Moser, P Loetscher
Apr 9, 2001·Infection and Immunity·H Kang, Y Suzuki
Aug 14, 2001·Infection and Immunity·S K HalonenL M Weiss
Feb 14, 2002·Scandinavian Journal of Immunology·X-B WangA K Lefvert
Apr 6, 2002·Acta Neuropathologica·Andreas StrackMartina Deckert
Aug 7, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Andrea SalmaggiMarco De Rossi
Aug 27, 2002·The Journal of Infectious Diseases·Daniel AjzenbergMarie-Laure Dardé
Jan 16, 2003·Immunology Letters·Bernhard Moser, Lisa Ebert
Jan 30, 2003·Glia·Juliana Croitoru-LamouryDominique Dormont
Apr 19, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hoil KangYasuhiro Suzuki
Oct 7, 2003·Inflammation·Jay S FineLoretta A Bober
Jul 24, 2004·Infection and Immunity·Xisheng WangYasuhiro Suzuki
Dec 28, 2004·International Journal for Parasitology·Yasuhiro SuzukiTakane Kikuchi
Apr 13, 2005·International Immunology·Daren R UreMoses Rodriguez
Jun 17, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Xisheng WangYasuhiro Suzuki
Jun 23, 2006·PLoS Pathogens·Imtiaz A KhanAndrew D Luster
May 5, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Xisheng WangYasuhiro Suzuki
Sep 18, 2008·Current Eye Research·Keiko KomatsuYoshitsugu Inoue
Mar 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kevin N CouperLawrence L Johnson
Citations
Oct 19, 2011·Expert Reviews in Molecular Medicine·Yasuhiro SuzukiEri Ochiai
Feb 23, 2013·Infection and Immunity·Alexis BoydRoshanak Tolouei Semnani
Feb 5, 2013·Journal of Neuroinflammation·Marbel TorresIsabelle Dimier-Poisson
Feb 24, 2016·Cell Cycle·Dan LiHong-Bing Shu
Nov 29, 2014·The American Journal of Pathology·Eri OchiaiYasuhiro Suzuki
Feb 22, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Rachel E Kneeland, S Hossein Fatemi
Dec 1, 2015·Journal of Neuroimmunology·Guilherme D MeloGisele F Machado
Jan 22, 2015·Scientific Reports·Maki NishimuraYoshifumi Nishikawa
Jun 27, 2014·Scandinavian Journal of Immunology·M PanarinaR Uibo
Mar 26, 2014·PloS One·Jaroslav FlegrZafar H Israili
Nov 12, 2016·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Jordan WarfordAlexander S Easton
Aug 19, 2017·ASN Neuro·Carla M CabralAnita A Koshy
Nov 12, 2016·MBio·Shinya HidanoChristopher A Hunter
Jan 31, 2014·Infection and Immunity·Crystal Tobin MagleLaura J Knoll
Jun 12, 2019·Infection and Immunity·Ye LiJianchun Xiao
Jan 4, 2020·Journal of Virology·Adrish SenHarry B Greenberg
Nov 21, 2015·Oncotarget·Chiuan-Ren YehShuyuan Yeh
Jun 21, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qila SaYasuhiro Suzuki
Mar 4, 2017·Molecular Genetics and Genomics : MGG·Ekaterina V MedvedevaLyudmila V Dergunova
Aug 18, 2017·Scientific Reports·Guilherme D MeloThierry Lang
Jul 18, 2018·Journal of Neuroinflammation·Joshua S StoolmanBenjamin M Segal
Oct 25, 2013·Molecular Medicine Reports·Haiyan HuangBingyi Shi
Jul 2, 2020·The Journal of Clinical Investigation·Xiao-Yu Zhao, Sarah E Ewald
May 28, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joanna E KlementowiczQizhi Tang
Feb 21, 2018·Frontiers in Immunology·Jing XiaHong-Juan Peng
Nov 8, 2017·Frontiers in Immunology·Frederick AllenAlex Y Huang
Oct 28, 2020·PLoS Pathogens·Katherine M StillTajie H Harris
Nov 27, 2020·Clinical Microbiology Reviews·Hany M ElsheikhaXing-Quan Zhu
Mar 27, 2021·Frontiers in Immunology·Maguy HamieHiba El Hajj
May 24, 2021·Acta Tropica·Ayse Caner
Jul 16, 2021·Frontiers in Immunology·Maguy HamieHiba El Hajj
Jun 13, 2014·Journal of Neuroinflammation·Deidre JanssonMike Dragunow