Predominant role of neural arc in sympathetic baroreflex resetting of spontaneously hypertensive rats

Circulation Journal : Official Journal of the Japanese Circulation Society
Yusuke SataMasaru Sugimachi

Abstract

There is ongoing controversy over whether neural or peripheral factors are the predominant cause of hypertension. The closed-loop negative feedback operation of the arterial baroreflex hampers understanding of how arterial pressure (AP) is determined through the interaction between neural and peripheral factors. METHODS AND RESULTS: A novel analysis of an isolated open-loop baroreceptor preparation to examine sympathetic nervous activity (SNA) and AP responses to changes in carotid sinus pressure (CSP) in adult spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY) was conducted. In the neural arc (CSP-SNA relationship), the midpoint pressure (128.9±3.8 vs. 157.9±8.1 mmHg, P<0.001) and the response range of SNA to CSP (90.5±3.7 vs. 115.4±7.6%/mmHg, P=0.011) were higher in SHR. In the peripheral arc (SNA-AP relationship), slope and intercept did not differ. A baroreflex equilibrium diagram was obtained by depicting neural and peripheral arcs in a pressure-SNA plane with rescaled SNA (% in WKY). The operating-point AP (111.3±4.4 vs. 145.9±5.2 mmHg, P<0.001) and SNA (90.8±3.2 vs. 125.1±6.9% in WKY, P<0.001) were shifted towards a higher level in SHR. The shift of the neural arc towards a higher SNA range in...Continue Reading

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Citations

Nov 7, 2015·The Journal of Physiological Sciences : JPS·Toru Kawada, Masaru Sugimachi
Mar 10, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Yoshitaka Hirooka
Jun 10, 2015·Current Heart Failure Reports·Una BuckleyJeffrey L Ardell
Jul 5, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Masafumi FukumitsuMasaru Sugimachi
Nov 10, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Toru KawadaMasaru Sugimachi
Feb 22, 2018·Journal of Hypertension·Yusuke SataMarkus P Schlaich
Mar 10, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Toru KawadaMasaru Sugimachi
May 31, 2018·Journal of Hypertension·Yusuke SataMarkus P Schlaich
May 10, 2020·Current Hypertension Reports·Yusuke SataDavid M Kaye
Sep 16, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mohsen MoslehpourRamakrishna Mukkamala
Mar 27, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Toru KawadaMasaru Sugimachi
Nov 11, 2019·The Journal of Physiological Sciences : JPS·Hidehiro NakaharaTadayoshi Miyamoto
Jan 23, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mohsen MoslehpourRamakrishna Mukkamala
Apr 14, 2018·Frontiers in Medicine·Yusuke SataMarkus P Schlaich

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