Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma

The New England Journal of Medicine
D S RobinsonA B Kay


In atopic asthma, activated T helper lymphocytes are present in bronchial-biopsy specimens and bronchoalveolar-lavage (BAL) fluid, and their production of cytokines may be important in the pathogenesis of this disorder. Different patterns of cytokine release are characteristic of certain subgroups of T helper cells, termed TH1 and TH2, the former mediating delayed-type hypersensitivity and the latter mediating IgE synthesis and eosinophilia. The pattern of cytokine production in atopic asthma is unknown. We assessed cells obtained by BAL in subjects with mild atopic asthma and in normal control subjects for the expression of messenger RNA (mRNA) for interleukin-2, 3, 4, and 5, granulocyte-macrophage colony-stimulating factor (GM-CSF), and interferon gamma by in situ hybridization with 32P-labeled complementary RNA. Localization of mRNA to BAL T cells was assessed by simultaneous in situ hybridization and immunofluorescence and by in situ hybridization after immunomagnetic enrichment or depletion of T cells. As compared with the control subjects, the subjects with asthma had more BAL cells per 1000 cell that were positive for mRNA for interleukin-2 (P less than 0.05), 3 (P less than 0.01), 4 (P less than 0.001), and 5 (P less th...Continue Reading


Mar 26, 1999·European Journal of Immunology·T JungC H Heusser
Jul 6, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·F Brombacher
Nov 28, 2000·European Journal of Immunology·A D BlanchardB R Champion
Dec 18, 2001·European Journal of Immunology·L M Ribeiro-do-CoutoC J Boog
Aug 14, 1998·Journal of Clinical Pharmacology·S C Lazarus
Jan 1, 1995·Journal of Clinical Laboratory Analysis·K Enssle, G Schulz
Nov 1, 1992·Pediatric Pulmonology·A K KamadaS J Szefler
Sep 1, 1994·Stem Cells·S F ZieglerM R Alderson
Feb 10, 2000·Springer Seminars in Immunopathology·T Biedermann, M Röcken
May 1, 1995·Journal of Clinical Immunology·S Romagnani
Jul 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·I PaegelowU Wartner
Jul 1, 1997·Clinical Reviews in Allergy & Immunology·I Kimber, R J Dearman
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Janet M Shapiro
Mar 17, 2007·Cellular and Molecular Life Sciences : CMLS·S G Trivedi, C M Lloyd
Sep 17, 2004·Journal of Human Genetics·Byung Lae ParkHyoung Doo Shin
Sep 1, 2005·Journal of Clinical Immunology·B SchaubP W Finn
May 12, 2011·Journal of Clinical Immunology·Rituparna DasRichard Bucala
Aug 2, 2013·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Xiao-Xia LuHe-Bin Chen
Mar 15, 2002·Current Allergy and Asthma Reports·F Runa AliMark Larché
Jan 22, 2005·Current Allergy and Asthma Reports·Marina Ostroukhova, Anuradha Ray
Feb 3, 2005·Current Allergy and Asthma Reports·Christopher E Brightling, Peter Bradding
Aug 10, 2012·Current Allergy and Asthma Reports·Zhaleh J Amini-VaughanDavid P Huston
Aug 11, 2006·Current Allergy and Asthma Reports·Zoë UrryCatherine M Hawrylowicz
Dec 23, 2008·Archives of Pharmacal Research·Ok-Kyoung KwonHyeong-Kyu Lee
Sep 10, 2011·Protein & Cell·Zhenhu LiBing Sun
Jun 4, 1993·European Journal of Pharmacology·A J Van OosterhoutF P Nijkamp
Sep 15, 1995·European Journal of Pharmacology·S Z AnticevichC L Armour
May 1, 1993·Trends in Pharmacological Sciences·F Powrie, R L Coffman
Sep 1, 1994·Trends in Pharmacological Sciences·G P Anderson, A J Coyle
Dec 1, 1992·Immunology Today·C Corrigan, A B Kay
Jun 1, 1993·Immunology Today·F Powrie, R L Coffman


Sep 1, 1990·The Journal of Experimental Medicine·D T WongJ McBride
Nov 1, 1990·The Journal of Experimental Medicine·K HiraiT Miyamoto
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P ParronchiS Romagnani
May 1, 1991·The Journal of Clinical Investigation·Q HamidP K Jeffery
Jun 1, 1990·Immunology Today·P C Beverley
Dec 1, 1990·The American Review of Respiratory Disease·M AzzawiA B Kay
Dec 1, 1989·The American Review of Respiratory Disease·P K JefferyA B Kay
Jan 1, 1988·The Journal of Experimental Medicine·A F LopezM A Vadas
May 21, 1988·Lancet·C CorriganA B Kay
Sep 1, 1988·Immunology Today·K Bottomly
Mar 1, 1989·The Journal of Infectious Diseases·C H FoxA S Fauci
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·H SaitoT Ishizaka
Jan 1, 1987·Immunology Today·T R Mosmann, R L Coffman

Related Concepts

Establishment and Maintenance of Localization
Pathogenic Aspects
Interferon Gamma Measurement
Immunofluorescence Assay
Bronchial System
Dermatitis, Atopic
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.


This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.