Preeclampsia - will orphan drug status facilitate innovative biological therapies?

Frontiers in Surgery
Sinuhe Hahn

Abstract

It is generally accepted that the development of novel therapies to treat pregnancy-related disorders, such as preeclampsia, is hampered by the paucity of research funding. Hence, it is with great interest to become aware of at least three novel therapeutic approaches for the treatment of this disorder: exploiting either the anticoagulant activity of antithrombin, the free radical scavenging activity of alpha-1-microglobulin, or the regenerative capacity of placenta-derived mesenchymal stem cells. As these projects are being carried out by small biotech enterprises, the question arises of how they are able to fund such undertakings. A novel strategy adopted by two of these companies is that they successfully petitioned US and EU agencies in order that preeclampsia is accepted in the register of rare or orphan diseases. This provides a number of benefits including market exclusivity, assistance with clinical trials, and dedicated funding schemes. Other strategies to supplement meager research funds, especially to test novel approaches, could be crowdfunding, a venture that relies on intimate interaction with advocacy groups. In other words, preeclampsia meets Facebook. Perhaps similar strategies can be adopted to examine novel t...Continue Reading

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Citations

Mar 17, 2015·Expert Review of Molecular Diagnostics·Sinuhe HahnNandor Gabor Than
Jan 23, 2016·Clinical and Experimental Hypertension : CHE·Emine IrgeEmre Karakus
Mar 5, 2016·Cell Adhesion & Migration·Stavros GiaglisSinuhe Hahn
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May 11, 2019·BMC Pregnancy and Childbirth·Sophia GrimesDaniel J Corsi
Jul 1, 2020·Biomolecules·Manoj Kumar JenaNihar Ranjan Nayak

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