Preeclampsia acts differently in in vitro fertilization versus spontaneous twins

Archives of Gynecology and Obstetrics
Rania OkbyEyal Sheiner

Abstract

To investigate risk factors and pregnancy outcome of spontaneous vs in-vitro fertilization (IVF) twins complicated with preeclampsia. A retrospective population-based cohort study comparing maternal and neonatal outcome in IVF vs spontaneously conceived twins was conducted. Deliveries occurred in a tertiary medical center between the years 1988 and 2010. Women who conceived after ovulation induction and those with chronic hypertension were excluded from the study. Multiple logistic regression models were used to control for confounders. The study population included 4428 twin pregnancies, of these 314 (7.1%) had preeclampsia; 64 (20.3%) were IVF twins and 250 (79.7%) were spontaneous twins. Preeclampsia was more common in IVF compare to spontaneous twins (13.8 vs 7.6%, OR = 1.81, CI = 1.50-2.17, P < 0.001). The mothers of IVF twins were significantly older, and were more likely to be nulliparous. The rate of cesarean delivery was higher among IVF twins. The mean gestational age at delivery and the mean birth weight were significantly lower in IVF twins. While controlling for confounders using a multivariate analysis, IVF was found as an independent risk factor for preterm delivery in twin pregnancies with preeclampsia. However,...Continue Reading

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Citations

Oct 24, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Paola AlgeriPatrizia Vergani
Mar 5, 2020·Journal of Developmental Origins of Health and Disease·Majdi ImteratAsnat Walfisch
Oct 5, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Lisa Barchilon-TiosanoRania Okby-Cronin
May 2, 2020·Journal of Clinical Medicine·Eliel Kedar SadeEyal Sheiner
Dec 3, 2020·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Sharon DavideskoEyal Sheiner
Nov 20, 2020·Current Hypertension Reports·Kavita Narang, Linda M Szymanski
May 28, 2021·Risk Management and Healthcare Policy·Ying WangHaitao Shen

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