Preeclampsia As Modulator of Offspring Health

Biology of Reproduction
Violeta StojanovskaTorsten Plösch

Abstract

A balanced intrauterine homeostasis during pregnancy is crucial for optimal growth and development of the fetus. The intrauterine environment is extremely vulnerable to multisystem pregnancy disorders such as preeclampsia, which can be triggered by various pathophysiological factors, such as angiogenic imbalance, immune responses, and inflammation. The fetus adapts to these conditions by a mechanism known as developmental programming that can lead to increased risk of chronic noncommunicable diseases in later life. This is shown in a substantial number of epidemiological studies that associate preeclampsia with increased onset of cardiovascular and metabolic diseases in the later life of the offspring. Furthermore, animal models based predominantly on one of the pathophysiological mechanism of preeclampsia, for example, angiogenic imbalance, immune response, or inflammation, do address the susceptibility of the preeclamptic offspring to increased maternal blood pressure and disrupted metabolic homeostasis. Accordingly, we extensively reviewed the latest research on the role of preeclampsia on the offspring's metabolism and cardiovascular phenotype. We conclude that future research on the pathophysiological changes during preecl...Continue Reading

References

Apr 1, 1992·British Journal of Obstetrics and Gynaecology·S A HinchliffeD Van Velzen
Jul 1, 1994·American Journal of Obstetrics and Gynecology·M M FaasW W Bakker
Mar 17, 1999·American Journal of Obstetrics and Gynecology·J F McCarthyJ M Roberts
Apr 9, 1999·The Journal of Clinical Investigation·G WallukatF C Luft
Feb 26, 2000·Metabolism: Clinical and Experimental·H LaivuoriO Ylikorkala
Mar 23, 2000·Archives of Gynecology and Obstetrics·N YaacobiA Hochman
Feb 7, 2001·Stroke; a Journal of Cerebral Circulation·J G ErikssonD J Barker
Jul 6, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S W WalshL J Roberts
Mar 21, 2002·American Journal of Obstetrics and Gynecology·Rønnaug A OdegårdRigmor Austgulen
Apr 5, 2002·Current Atherosclerosis Reports·Braxton D Mitchell, Ikhide G Imumorin
Mar 12, 2003·The Journal of Clinical Endocrinology and Metabolism·Sirpa TenholaRaimo Voutilainen
Jun 25, 2003·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·R XiaoD A Luthy
Jan 13, 2004·Human Reproduction Update·A MalassinéD Evain-Brion
Sep 30, 2004·Free Radical Research·Hirokazu TsukaharaMitsufumi Mayumi
Oct 28, 2004·Thrombosis Research·Neil M GudeRoger G King
Dec 16, 2004·The Journal of Clinical Investigation·Shigetada FurukawaIichiro Shimomura
Mar 19, 2005·Pediatric Research·Hugo Brandt CorstiusM Jane Black
Mar 2, 2006·Cell and Tissue Research·Samuel LiévanoLorenza González-Mariscal
Mar 22, 2006·Pediatric Research·Deepali Pitre PoladiaCarlton M Bates
Jun 6, 2006·Nature Medicine·Shivalingappa VenkateshaS Ananth Karumanchi
Jun 16, 2006·Journal of Perinatology : Official Journal of the California Perinatal Association·R-J TengM L Hudak
Jul 26, 2006·Pediatric Research·Jovanna DahlgrenAgneta Holmäng
Aug 26, 2006·Nature Clinical Practice. Nephrology·Marina NorisGiuseppe Remuzzi
Aug 26, 2006·Nature Clinical Practice. Cardiovascular Medicine·Rebecca L Pollex, Robert A Hegele
Sep 8, 2006·The New England Journal of Medicine·Richard J LevineUNKNOWN CPEP Study Group
Sep 22, 2006·Pediatric Research·Kristin BraekkeAnne C Staff
Oct 28, 2006·Acta Obstetricia Et Gynecologica Scandinavica·Ella OphirJacob Bornstein
Jan 16, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Masahito KajiyaFumihiko Kajiya
Jun 15, 2007·American Journal of Reproductive Immunology : AJRI·Alpana SharmaJai Bhagwan Sharma
Sep 18, 2007·Circulation Research·Ronghua Yang, Lili A Barouch

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Citations

May 5, 2017·American Journal of Hypertension·Eric M GeorgeJoey P Granger
Nov 25, 2018·BJOG : an International Journal of Obstetrics and Gynaecology·Y ChenY Zhang
Jan 27, 2019·Disease Models & Mechanisms·Violeta StojanovskaTorsten Plösch
Apr 11, 2019·Journal of Developmental Origins of Health and Disease·V StojanovskaT Plösch
May 28, 2019·European Journal of Preventive Cardiology·Maria Ac JansenLenie van Rossem
Mar 18, 2017·Clinical Science·Anjali ChauhanLouise D McCullough
Feb 20, 2020·Journal of Developmental Origins of Health and Disease·Prabha H AndraweeraClaire T Roberts
May 21, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John Henry DasingerDavid L Mattson
Aug 25, 2019·BMC Pregnancy and Childbirth·Nisha S WadhwaniSadhana R Joshi
Nov 18, 2018·Journal of Cellular Physiology·Zengfang WangYingliang Wang
Jul 28, 2020·The Journal of Pediatrics·I-Chun LinLi-Tung Huang
Dec 31, 2019·Current Pediatric Reviews·Ageliki A Karatza, Gabriel Dimitriou
Jun 3, 2021·International Journal of Molecular Sciences·Lars BrodowskiFrauke von Versen-Höynck
Jul 25, 2021·Journal of Clinical Medicine·Wiktor WojczakowskiBożena Leszczyńska-Gorzelak
Sep 14, 2021·Frontiers in Immunology·Marilen BennerAstrid Hogenkamp
Nov 16, 2021·Frontiers in Immunology·Dorien FeyaertsRenate G van der Molen
Oct 7, 2021·American Journal of Respiratory Cell and Molecular Biology·Elizabeth S TaglauerStella Kourembanas

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