Preeclampsia in pregnancy and later use of antihypertensive drugs

European Journal of Epidemiology
Anders EngelandKari Furu

Abstract

We explored the association between preeclampsia and later use of antihypertensive drugs in a population-based study with data from the Medical Birth Registry of Norway and the Norwegian Prescription Database. The study cohort consisted of 980,000 women having 2.1 million pregnancies during 1967-2012. Hazard ratios (HRs) with 95% confidence intervals (95% CI) were estimated in multivariate time-dependent Cox proportional hazards regression models. Overall, the HR of later use of antihypertensive drugs was 2.0 (95% CI 2.0-2.0) in women with one preeclamptic pregnancy compared to women without preeclamptic pregnancies. The HR increased by increasing number of preeclamptic pregnancies, both term and preterm pregnancies. In women with two or more preeclamptic pregnancies, the HR was 2.8 (2.7-3.0). The overall HR after 40 years of follow-up for women with one preeclamptic pregnancy was 1.3 (1.2-1.4) and for two or more preeclamptic pregnancies the HR was 1.6 (1.1-2.1). The first 5 years after the first birth, the HR of being dispensed antihypertensive drugs was higher in preterm [8.4 (7.7-9.1)] than term preeclamptic pregnancies [4.3(4.0-4.6)]. However, after 10 years, this difference was no longer present. The HR of later use of an...Continue Reading

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Citations

Oct 25, 2017·European Journal of Epidemiology·M Arfan IkramAlbert Hofman
Jul 7, 2018·BJOG : an International Journal of Obstetrics and Gynaecology·L BrouwersB B van Rijn
Aug 3, 2020·BJOG : an International Journal of Obstetrics and Gynaecology·K J GrayR Saxena
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Mar 19, 2020·Drug Design, Development and Therapy·Catherine LeggettSanjay Garg
Nov 17, 2020·Circulation. Cardiovascular Imaging·Laura BenschopUNKNOWN CREW Consortium

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