PMID: 9420866Jul 1, 1995Paper

Preeclampsia is associated with decreased placental interleukin-6 production

Journal of the Society for Gynecologic Investigation
S W KaumaS W Walsh

Abstract

The etiology of preeclampsia is poorly understood, but may involve abnormal fetal-maternal immunologic interactions. Interleukin-6 (IL-6) is a multifunctional immunologic cytokine that is normally produced by the placenta during pregnancy. Recent studies have shown that amniotic fluid IL-6 is decreased in pregnancies complicated by preeclampsia. Consequently, this study was designed to test the hypothesis that placental IL-6 production is decreased in preeclampsia. Placental explants from normal (N = 6) and preeclamptic (N = 6) pregnancies were cultured in vitro, and the media were sampled at 0, 2, 6, 16, 28, and 48 hours. Production rates of IL-6 were measured by enzyme-linked immunosorbent assay, and relative IL-6 mRNA expression was measured by Northern and dot blot analyses. Production rates of IL-6 were 2.3-fold lower in preeclamptic placentas than in normal placentas, at 146 pg/microgram/hour versus 341 pg/microgram/hour (P < .05). However, relative steady-state IL-6 mRNA expression was identical in preeclamptic and normal placentas. Placental IL-6 production is decreased in preeclampsia. The decrease in placental IL-6 production and secretion in preeclampsia is regulated by a post-transcriptional mechanism.

Citations

Oct 7, 2000·Bulletin of Experimental Biology and Medicine·S A Sel'kovA V Selyutin
Aug 15, 2002·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·G GalaziosP Anastasiadis
Oct 17, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Augusta M A LachmeijerReynir Arngrímsson
Jun 14, 2002·Mediators of Inflammation·Jacek R WilczyńskiJan Wilczyński
Aug 19, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Alaa AmashMahmoud Huleihel
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Jul 12, 2007·Seminars in Immunopathology·Corinne RusterholzWolfgang Holzgreve
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Jun 15, 2007·American Journal of Reproductive Immunology : AJRI·Bunyamin BorekciSedat Kadanali
May 10, 2008·The American Journal of Pathology·Charles J LockwoodFrederick Schatz
Sep 18, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Monia CecatiMonica Emanuelli
Mar 14, 2003·American Journal of Obstetrics and Gynecology·Peter TakacsScott W Kauma
Apr 29, 2015·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Sabnavis SowmyaAnanthapur Venkateshwari
Aug 22, 2007·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Bei XuAnnemarie Hennessy

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