Preeclampsia is not associated with elevated muscle sympathetic reactivity.

Journal of Applied Physiology
Laura Marcela ReyesMargie H Davenport

Abstract

To determine whether increased chemoreflex tonic activity is associated with augmented muscle sympathetic nervous system activity (MSNA) in women diagnosed with preeclampsia. Women with preeclampsia (n = 19; 32 ± 5 yr old, 31 ± 3 wk of gestation) were matched by age and gestational age with pregnant women (controls, n = 38, 32 ± 4 yr old, 31 ± 4 wk gestation; 2:1 ratio). MSNA (n = 9 preeclampsia) was assessed during baseline, peripheral chemoreflex deactivation (hyperoxia), and a cold pressor test (CPT). Baroreflex gain and diastolic blood pressure at which there is a 50% likelihood of MSNA occurring (T50) and plasma noradrenaline concentrations were measured. Baseline mean arterial pressure (MAP: 106 ± 11 vs. 87 ± 10 mmHg, P < 0.0001), noradrenaline concentrations (498 ± 152 pg/mL vs. 326 ± 147, P = 0.001), and T50 (79 ± 7 vs. 71 ± 9 mmHg, P = 0.02) were greater in women with preeclampsia than in controls. However, baseline MSNA (burst incidence [BI]: 41 ± 16 vs. 45 ± 13 bursts/100 hb, P = 0.4) was not different between groups. Responses to hyperoxia (ΔBI -5 ± 7 vs. -1 ± 8 bursts/100 hb, P = 0.1; ΔMAP -1 ± 3 vs. -2 ± 3 mmHg, P = 0.7) and CPT (ΔBI 15 ± 7 vs. 12 ± 11 bursts/100 hb, P = 0.6; ΔMAP 10 ± 4 vs. 12 ± 11 mmHg, P = 0.6)...Continue Reading

References

Jun 1, 1971·The Journal of Pharmacy and Pharmacology·M Henning, A Rubenson
May 1, 1993·Journal of Applied Physiology·K H WesselingJ J Schreuder
Nov 14, 1996·The New England Journal of Medicine·H P SchobelR E Schmieder
Oct 31, 1998·Journal of Hypertension·J P GreenwoodD A Mary
Sep 7, 1999·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·R J KaajaM G Nicholls
Apr 14, 2000·American Journal of Obstetrics and Gynecology·S KhatunT Terao
Mar 7, 2003·American Journal of Hypertension·John P GreenwoodDavid A S G Mary
Jun 18, 2004·European Journal of Clinical Investigation·T FischerK Heusser
Mar 1, 2005·Lancet·Baha SibaiMichael Kupferminc
Mar 4, 2005·BMJ : British Medical Journal·Kirsten Duckitt, Deborah Harrington
Mar 22, 2005·Brain Research·Tarek M SalehAlastair E Cribb
Jan 17, 2008·American Journal of Physiology. Endocrinology and Metabolism·Yrsa Bergmann SverrisdóttirElisabet Stener-Victorin
Dec 17, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Emma C HartNisha Charkoudian
Sep 14, 2010·Journal of Neuroscience Methods·Aryan SalmanpourJ Kevin Shoemaker
Feb 22, 2011·Best Practice & Research. Clinical Obstetrics & Gynaecology·Jennifer A HutcheonK S Joseph
Oct 1, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jordan S QueridoA William Sheel
Dec 14, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Maciej SińskiZbigniew Gaciong
Jun 13, 2012·The Journal of Physiology·Sara S JarvisQi Fu
Sep 5, 2013·Nature Communications·Fiona D McBrydeJulian F R Paton
Aug 12, 2014·The Lancet Global Health·Lale SayLeontine Alkema
Jun 9, 2015·Journal of the American Society of Hypertension : JASH·Marat FudimFernando Elijovich
Jul 4, 2015·Journal of Applied Physiology·Charlotte W UsselmanCraig D Steinback
Feb 9, 2017·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S de HaasM E A Spaanderman
Jul 25, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Nisha CharkoudianCraig D Steinback
Oct 20, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sydney M L SchmidtCraig D Steinback
Oct 25, 2017·Hypertension·Styliani Goulopoulou
Jan 18, 2018·Experimental Physiology·Laura M ReyesCraig D Steinback
Aug 24, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Graeme M PurdyCraig D Steinback
Feb 15, 2019·Experimental Biology and Medicine·Roongrit KlinjampaTripop Lertbunnaphong
May 21, 2019·The Journal of Physiology·Craig D SteinbackMargie H Davenport
Apr 18, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Laura M ReyesMargie H Davenport

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

APD
ADInstruments Peak Detection
LabChart
GraphPad
GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.