Preemptive cadaveric renal transplantation--clinical outcome

Transplantation
J A RoakeP J Morris

Abstract

Preemptive cadaveric renal transplantation (PCRT) maximizes the chance of maintaining high quality of life and may avoid the morbidity of dialysis and the associated financial costs. These benefits are offset by disadvantages, which include the possibility of transplantation many months before the need for dialysis, resulting in wasted organ function; an immediate risk of graft failure with conversion to a dialysis-dependent state; and uncertainty of the safety of PCRT. Patients who underwent PCRT between June 1976 and December 1994 at the Oxford Transplant Centre were compared with a matched cohort of first cadaveric transplant recipients who were dialysis-dependent when transplanted. The 116 patients in the PCRT cohort were well matched to the control group with respect to sex, age, blood group, HLA match, degree of sensitization, donor age, immunosuppression, and year of transplantation. Patient and graft survival were significantly better in the PCRT group. The difference in graft survival did not appear to be completely explained by better patient survival, as suggested by a trend toward better graft survival after excluding death with a functioning graft as a cause of failure. Among surviving grafts there were no signific...Continue Reading

References

Jan 1, 1976·Scandinavian Journal of Immunology·S A Birkeland
Jan 1, 1988·The British Journal of Surgery·R M JonesP J Morris
Jan 1, 1987·Transplantation·R J MiglioriD Fryd
Mar 6, 1982·Lancet·P J MorrisA Ting
May 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B M Brenner, E L Milford
Mar 22, 1957·Annals of the New York Academy of Sciences·G J DAMMINJ E MURRAY

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Citations

Jul 5, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hasan OtukeshMohamad Fereshtenejad
Jan 9, 2010·International Urology and Nephrology·Adam RemportMiklos Zsolt Molnar
Nov 13, 2003·Transplantation Proceedings·N SimforooshS Farhangi
May 1, 2001·International Journal of Urology : Official Journal of the Japanese Urological Association·H HaradaT Koyanagi
Sep 6, 2000·Kidney International·H U Meier-KriescheB Kaplan
Aug 13, 1998·Transplantation·A G JohnC K Jacob
May 29, 2004·Transplantation·Amgad E el-AgroudyMohamed A Ghoneim
Sep 24, 2004·Transplantation·John S GillBrian J G Pereira
Sep 11, 2009·Transplantation·Bartlomiej J WitczakAnders Hartmann
Nov 9, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Greg KnollUNKNOWN Kidney Transplant Working Group of the Canadian Society of Transplantation
Mar 22, 2012·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Ming LuoZhihua Zhou
Oct 29, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Francis L Weng, Kevin C Mange
Jan 7, 2003·Internal Medicine Journal·S PrasadR Faull
Mar 25, 2014·Transplantation Proceedings·M TasakiK Takahashi
Oct 4, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Françoise G PradelStephen T Bartlett
Sep 22, 2009·Transplantation Proceedings·M HaberalG Arslan
Mar 3, 2009·Transplantation Proceedings·S W YooC M Kang
Nov 7, 2007·Endocrinology and Metabolism Clinics of North America·Rajani Dinavahi, Enver Akalin
Dec 19, 2006·Transplantation Proceedings·H KishikawaM Nojima
Feb 26, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Connie L Davis
Jan 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Ajay K IsraniKevin C Mange
Oct 4, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Kevin C Mange, Matthew R Weir
Jun 15, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K CransbergG G Persijn
Dec 16, 2010·Transplant International : Official Journal of the European Society for Organ Transplantation·Michèle KesslerFrançois Alla
Mar 1, 2006·Transplantation Proceedings·A Debska-SlizieńB Rutkowski
Jan 9, 2004·Pediatric Clinics of North America·Mark R Benfield
Apr 17, 2015·Transplant International : Official Journal of the European Society for Organ Transplantation·Natacha RiffautBruno Hurault de Ligny
Nov 1, 2015·Transplantation Proceedings·E A FloritF Diekmann
Jul 21, 2017·Pediatric Transplantation·Patricia L WengEileen Tsai Chambers
Aug 14, 2018·Clinical Transplantation·Jennifer C GanderRachel E Patzer
Dec 13, 2018·ILAR Journal·Jeffrey L PlattJorge A Piedrahita
Nov 24, 2017·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Jacob W Potts, Shaker A Mousa
Sep 19, 2002·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Rajko HrvacevićMihailo Marić
Apr 19, 2002·Journal of the American Society of Nephrology : JASN·Bertram L KasiskeAnnamaria T Kausz
Jun 10, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G MontagninoC Ponticelli
Mar 7, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation

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