Preemptive multimodal analgesia for postoperative pain management after lumbar fusion surgery: a randomized controlled trial

European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
Sang-Il KimIn-Soo Oh

Abstract

To assess the efficacy of a novel preemptive multimodal analgesic regimen for reducing postoperative pain and complications after primary lumbar fusion surgery. Preemptive multimodal analgesia is revealed to be an effective alternative to conventional morphine administration providing improved postoperative pain control with diminished side effects. However, an optimal regimen for spinal fusion surgery remains unknown. After Institutional Review Board approval, 80 patients who underwent primary lumbar 4-5 fusion surgery were randomly assigned to receive either only intravenous morphine or a preemptive multimodal (celecoxib, pregabalin, extended-release oxycodone, and acetaminophen) analgesic regimen. Postoperative pain and functional levels were measured by the visual analog scale (VAS) and Oswestry Disability Index (ODI), respectively, and intraoperative blood loss, postoperative Hemovac drain output, and nonunion rates were evaluated for complications. No differences were observed in the patient demographics, intraoperative blood loss, postoperative Hemovac drain output, or nonunion rate between two groups. The VAS and ODI were lower at all postoperative time points, except the ODI on postoperative day 1 in patients randomize...Continue Reading

References

Jun 30, 1990·BMJ : British Medical Journal·S KuhnJ C Mucklow
Apr 1, 1988·Anesthesiology·S N RajaJ N Campbell
Jun 22, 1999·Lancet·D B Carr, L C Goudas
Jun 10, 2000·Science·C J Woolf, M W Salter
Apr 4, 2002·The Journal of the American Academy of Orthopaedic Surgeons·Raymond S SinatraArsenio M Bustos
Mar 18, 2003·Journal of Clinical Pharmacology·Edward J RandinitisHoward N Bockbrader
May 27, 2004·The Journal of the American Academy of Orthopaedic Surgeons·Laurence E Dahners, Brian H Mullis
Mar 3, 2005·The Journal of Bone and Joint Surgery. American Volume·Scott S Reuben, Evan F Ekman
Apr 4, 2006·Clinical Pharmacology and Therapeutics·Gisèle PickeringClaude Dubray
Jun 8, 2006·The Journal of Bone and Joint Surgery. American Volume·Angelo Salerno, Robert Hermann
Oct 24, 2006·Anesthesia and Analgesia·Scott S ReubenKarthik Raghunathan
Jun 5, 2007·The Journal of Bone and Joint Surgery. American Volume·Scott S Reuben, Asokumar Buvanendran
Jun 25, 2008·The Clinical Journal of Pain·Larry F ChuDavid Clark
Jan 20, 2009·Anesthesia and Analgesia·Andrew D Farmery, James Wilson-MacDonald
Nov 19, 2009·Journal of Orthopaedics and Traumatology : Official Journal of the Italian Society of Orthopaedics and Traumatology·Carlo Luca RomanòGiuseppe Mineo
May 7, 2013·Clinical Orthopaedics and Related Research·In Jun KohTae Kyun Kim
Jul 16, 2013·The Journal of Arthroplasty·Joseph D LamplotDavid W Manning

❮ Previous
Next ❯

Citations

Feb 13, 2016·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Jules GrezeJean-Francois Payen
Mar 16, 2017·The Journal of the American Academy of Orthopaedic Surgeons·Mark F KurdAlexander R Vaccaro
Feb 3, 2018·Pain Practice : the Official Journal of World Institute of Pain·Sergio TerracinaFederico Bilotta
Feb 23, 2019·Orthopaedic Nursing·Ida Anderson, Jessica Alger
Jul 22, 2017·Current Opinion in Anaesthesiology·Massimo LampertiRafi Avitsian
Aug 2, 2017·Clinical Orthopaedics and Related Research·Seth S Leopold, Lee Beadling
Jan 27, 2019·Journal of Orthopaedic Trauma·Joseph R HsuUNKNOWN Orthopaedic Trauma Association Musculoskeletal Pain Task Force
Nov 18, 2017·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Linda HeleniusIlkka Helenius
Sep 1, 2017·JBJS Reviews·Joseph T Labrum, Asif M Ilyas
Sep 28, 2017·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Hüseyin Ulaş PınarRafi Doğan
Nov 7, 2020·Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses·Elizabeth M TuckerVirginia C Muckler
Feb 22, 2021·World Neurosurgery·Maria P NtaloukaEleni M Arnaoutoglou
May 13, 2021·Pediatric Quality & Safety·Melissa A LoPrestiSandi K Lam

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.