Preemptive versus Non-preemptive simultaneous pancreas-kidney transplantation: a single-center, long-term, follow-up study

Transplantation
Menno T PruijmJan P Vandenbroucke

Abstract

Data regarding the timing-before or after initiation of dialysis-of simultaneous pancreas-kidney transplantation (SPKT) in type 1 diabetes mellitus patients with end-stage renal failure are sparse. We studied the effect of preemptive transplantation on patient survival, cardiovascular endpoints, and graft survival, as compared with non-preemptive transplantation. All 180 SPKT recipients (aged 23-58 years) who received a SPKT in Leiden between December 1986 and May 2004 were included in the analysis. Sixty-five patients (36.1%) were transplanted preemptively. Mean follow-up time was 6.3 years. Up to 8.2 years after transplantation, we found no differences in patient survival. Later on, divergence occurred: 10-year patient survival was 71.3% in the preemptive group versus 63.8% in the dialysis group and 15-year patient survival was 64.8% versus 45.1% in the dialysis group, leading to an adjusted hazard ratio for mortality of 0.50 (95% CI 0.23-1.06, P=0.070). Cause of death was less often of cardiac origin in the preemptive group (adjusted HR 0.16; 95% CI 0.026-0.95, P=0.044). Graft survival did not follow the same trend. No significant differences were found between the two groups considering allograft survival, cerebrovascular a...Continue Reading

References

May 15, 1997·Transplantation·E J SchweitzerS T Bartlett
Mar 31, 1998·Diabetes·O P PitkänenJ Knuuti
Jan 29, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K Sudhakar ReddyDinesh Ranjan
Jan 21, 2004·Blood Purification·Eberhard Ritz
Jun 10, 2004·The Journal of Clinical Hypertension·David S MarksJan L Houghton
Jan 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Ajay K IsraniKevin C Mange

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Citations

Sep 10, 2010·Current Opinion in Nephrology and Hypertension·Connie L Davis
Jun 26, 2012·Transplantation·Mathieu PageBernard Allaouchiche
Aug 5, 2015·Journal of Clinical Medicine·María José Pérez-Sáez, Julio Pascual
May 1, 2010·Transplantation Proceedings·S KallabN Kamar
Nov 7, 2007·Endocrinology and Metabolism Clinics of North America·Rajani Dinavahi, Enver Akalin
Apr 14, 2012·The Mount Sinai Journal of Medicine, New York·Anja RichterBernd Schröppel
Apr 10, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H de KortI M Bajema
Jul 20, 2007·Journal of the American Society of Nephrology : JASN·Stefan P BergerJohan W de Fijter
Nov 15, 2019·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Agnieszka SurowieckaMarek Durlik
Jun 2, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·Sandesh ParajuliDidier A Mandelbrot
Jul 19, 2008·Annals of the Royal College of Surgeons of England·S A White, D W Manas
Sep 18, 2017·Digestive Diseases and Sciences·Augusto LauroKishore R Iyer
Feb 3, 2021·Clinical Transplantation·Yinlei DongZhenhua Hu
Jul 11, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Ugo BoggiThierry Berney
May 26, 2009·Lancet·Steve A WhiteDavid E R Sutherland

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