Preexisting psychological stress predicts acute and chronic fatigue and arthritis following symptomatic parvovirus B19 infection

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Jonathan R Kerr, Derek L Mattey

Abstract

Psychological stress is thought to be an important factor in the pathogenesis of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). Therefore, we sought to examine this relationship in the context of parvovirus B19 infection. Thirty-nine patients with laboratory-documented acute parvovirus B19 infection were asked to complete questionnaires on negative life events, perceived stress, and negative affect relevant to the time of onset of parvovirus infection and during the preceding 12 months. These scores were combined into an overall stress index, which was then examined for associations with particular parvovirus-associated symptoms at acute infection and during the ensuing 1-3 years. Additional characteristics monitored included presence of parvovirus antibodies and nucleic acid, cortisol level, dehydroepiandrosterone level, autoantibodies, levels of a range of serum cytokines, and human leukocyte antigen class I and II alleles. Stress index was significantly associated with development of fatigue during the acute phase of parvovirus B19 infection and also with chronic fatigue and arthritis occurring 1-3 years following acute parvovirus B19 infection. Logistic regression that included all clinical variables indicated...Continue Reading

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Jul 2, 2010·Journal of Clinical Microbiology·D SchaudienC Herden
Apr 29, 2010·Current Psychiatry Reports·Boudewijn Van HoudenhovePatrick Luyten
Feb 2, 2010·Pediatric Neurology·Jonathan N JohnsonPhilip R Fischer
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Oct 5, 2018·Journal of Translational Medicine·Santa RasaUNKNOWN European Network on ME/CFS (EUROMENE)
Feb 26, 2019·Frontiers in Pediatrics·Lily ChuJose G Montoya

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