Preexposure Intradermal Rabies Vaccination: A Noninferiority Trial in Healthy Adults on Shortening the Vaccination Schedule From 28 to 7 Days

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Patrick SoentjensEmmanuel Bottieau

Abstract

The existing 4-week preexposure rabies vaccination schedule is costly and often not practicable. Shorter effective schedules would result in wider acceptance. We conducted a noninferiority trial in 500 healthy adults comparing the safety and immunogenicity of a 2-visit (days 0 and 7) intradermal (ID) primary vaccination (2 doses of 0.1 mL ID of the human diploid cell culture rabies vaccine [HDCV] at days 0 and 7) vs a standard 3-visit schedule (single dose of 0.1 mL ID at days 0, 7, and 28). One year to 3 years after primary vaccination, a single booster dose of 0.1 mL ID of HDCV was given to evaluate the anamnestic rabies antibody response. The primary endpoint for immunogenicity was the percentage of subjects with an adequate antibody level >0.5 IU/mL 7 days after the booster injection. The safety endpoint was the proportion of participants developing adverse reactions following the primary vaccination and/or booster dose. All subjects in both study groups possessed a rabies antibody titer >0.5 IU/mL on day 7 following the booster dose. Following the booster dose, subjects exposed to the double-dose 2-visit ID schedule had a geometric mean titer of 37 IU/mL, compared with 25 IU/mL for the single-dose 3-visit schedule (P < .00...Continue Reading

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References

Feb 26, 1982·JAMA : the Journal of the American Medical Association·K W BernardR Chaney
Aug 19, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Terapong TantawichienVisith Sitprija
Nov 5, 2004·The New England Journal of Medicine·Robert B BelsheGary Dubin
Nov 5, 2004·The New England Journal of Medicine·Richard T KenneyGregory M Glenn
Nov 5, 2004·The New England Journal of Medicine·John R La Montagne, Anthony S Fauci
Apr 18, 2007·Journal of Travel Medicine·Pakamatz KhawplodPranee Chomchey
Jan 15, 2008·Transactions of the Royal Society of Tropical Medicine and Hygiene·N C VienJ Lang
Jun 13, 2008·Vaccine·David BrownMartin Schweiger
Apr 11, 2009·Transactions of the Royal Society of Tropical Medicine and Hygiene·C StradyA Strady
Aug 19, 2010·Expert Opinion on Drug Delivery·Vanessa Vankerckhoven, Pierre Van Damme
Oct 5, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Prapimporn ShantavasinkulVisith Sitprija
Feb 22, 2012·Travel Medicine and Infectious Disease·M J Warrell
Oct 9, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R W WietenMartin P Grobusch
Feb 16, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Patrick SoentjensA Van Gompel
Apr 23, 2013·Lancet Neurology·Thiravat HemachudhaJiraporn Laothamatas
Jan 18, 2014·Vaccine·Betty DodetHelen Rees
May 12, 2015·PLoS Neglected Tropical Diseases·Katie HampsonGlobal Alliance for Rabies Control Partners for Rabies Prevention
Jul 8, 2015·Journal of Leukocyte Biology·Bastiaan A BlokMihai G Netea
Mar 3, 2017·Bulletin of the World Health Organization·Jocelyn A KesselsDeborah Briggs
May 23, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Annefleur C LangedijkCornelis Stijnis
Aug 16, 2018·Vaccine· World Health Organization

Citations

Apr 21, 2019·Military Medicine·Mathias D M Van NieuwenhovePatrick Soentjens
May 3, 2019·Journal of Travel Medicine·Johnnie A YatesGlobal TravEpiNet Consortium
Jul 16, 2019·Current Opinion in Infectious Diseases·Amrita Pattanaik, Reeta S Mani
Dec 11, 2019·Journal of Travel Medicine·Patrick Soentjens
Sep 3, 2020·Journal of Travel Medicine·Christoph HatzAndrea Farnham
Dec 20, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Patrick SoentjensEmmanuel Bottieau
Oct 18, 2020·Journal of Travel Medicine·Mieke Croughs, Patrick Soentjens
Sep 19, 2020·Journal of Travel Medicine·R Steffen, Davidson H Hamer
Oct 4, 2020·Journal of Travel Medicine·Patrick Soentjens, Mieke Croughs
Oct 17, 2019·Journal of Travel Medicine·Patrick Soentjens, Mieke Croughs
Feb 12, 2021·BMJ Global Health·Patrick SoentjensRaffaella Ravinetto
Apr 4, 2021·Journal of the Neurological Sciences·Pasin Hemachudha, Thiravat Hemachudha

Related Concepts

Clinical Trials
Rabies virus
Vaccination
Rabies Vaccination
Vaccines
Intradermal
Site
Adverse Reactions
Participant
Diploid Cell

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