PMID: 7535881Jan 1, 1994Paper

Prefabrication of a vascularized nerve graft by vessel implantation: preliminary report of an experimental model

Microsurgery
P C Cavadas, F J Vera-Sempere

Abstract

Regeneration through vascularized nerve grafts (VNG) seems to be better than nonvascularized nerve grafts (NVNG), especially in hostile beds. We report on an experimental technique of prefabrication of VNG by direct vessel implantation. An arteriovenous fistula was created in the groin region with autologous vein grafts in the Wistar rat model, and implanted into the sciatic nerve. Five weeks later the sciatic VNG was elevated on the prefabricated pedicle. The flap was free-transferred orthotopically over a silicone sheet to impede plasmatic imbibition. Flap viability at 3 days was complete. India ink injection of the AV fistula resulted in capillary ink filling within the nerve and surrounding tissues. Histologic sections of the flap were examined, revealing its neovascularity. In an ongoing study, the regeneration through this prefabricated VNG is being compared to native VNG.

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Citations

Feb 1, 1997·Plastic and Reconstructive Surgery·C Y Ko, W W Shaw
Feb 25, 2010·Annals of Plastic Surgery·Savaş SerelAylin Okçu Heper
Oct 20, 2018·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Papon MuangsanitJames B Phillips
Nov 13, 2019·Annals of Plastic Surgery·Pedro C Cavadas, Asia Torres
Feb 1, 1997·Acta Orthopaedica Scandinavica. Supplementum·M Rostek, W A Morrison

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