Preferable inotropic action of procaterol, a potent bronchodilator, on impaired diaphragmatic contractility in an intraabdominal septic model.

Journal of Anesthesia
Mitsuru UzukiAkiyoshi Namiki

Abstract

Intraabdominal sepsis can lead to acute respiratory failure, and concomitant diaphragmatic dysfunction may be aggravated by sepsis-induced airway hyperreactivity. We previously reported that isoproterenol, a nonselective beta-adrenoceptor agonist, increased diaphragmatic contractility and accelerated recovery from fatigue during sepsis. The purpose of this study was to demonstrate the direct inotropic effect of a potent bronchodilator and beta(2)-selective adrenoceptor agonist, procaterol, on fatigued diaphragmatic contractility in an intraabdominal septic model. Rats were divided into two groups: a cecal ligation and perforation (CLP) group and a sham group. CLP was performed in the CLP group whereas laparotomy alone was performed in the sham group. The left hemidiaphragm was removed at 16 h after the operation. The diaphragmatic tissues were exposed to procaterol (10(-8)-10(-6) M), and muscle contractility was assessed. Intracellular cyclic AMP levels were also measured in the CLP model. Procaterol caused an upward shift in the force-frequency curves in the CLP group whereas it had no effect on the curves in the sham group. Procaterol significantly increased cyclic AMP levels in the CLP model. We conclude that the potent bron...Continue Reading

References

Jan 1, 1991·Pharmacology & Therapeutics·J D Scott
Jan 1, 1990·Life Sciences·A J Van Oosterhout, F P Nijkamp
May 1, 1988·The American Review of Respiratory Disease·S SuzukiT Okubo
Aug 1, 1980·The Journal of Surgical Research·K A WichtermanI H Chaudry
Nov 1, 1993·The American Review of Respiratory Disease·G SupinskiA DiMarco
Jan 1, 1997·American Journal of Respiratory and Critical Care Medicine·E DeromM Decramer
Jun 6, 1998·Molecular and Cellular Biochemistry·S N Hussain
Feb 15, 2000·American Journal of Respiratory and Critical Care Medicine·N FujimuraA Namiki
Dec 9, 2000·American Journal of Respiratory and Critical Care Medicine·N FujimuraA Namiki

❮ Previous
Next ❯

Citations

Jan 11, 2017·Journal of Biosocial Science·Ndola PrataUshma D Upadhyay
Sep 29, 2012·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Cheng-Chang YangMau-Sun Hua

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.