Preference for a prefilled syringe or an auto-injection device for delivering golimumab in patients with moderate-to-severe ulcerative colitis: a randomized crossover study

Patient Preference and Adherence
Séverine VermeireFilip Baert

Abstract

Simponi® (golimumab, MSD) is a fully human monoclonal antibody against tumor necrosis factor alpha administered subcutaneously using an autoinjector or a prefilled syringe. This study examined preference for administration of golimumab by autoinjector or prefilled syringe in patients with moderate-to-severe ulcerative colitis (UC). This was a multicenter, open-label, randomized crossover trial (EudraCT no 2014-000656-29). Patients with moderate-to-severe UC were randomized 1:1 to receive 2 subcutaneous injections of 50 mg golimumab with the autoinjector followed by 2 injections of 50 mg with the prefilled syringe or the same 4 injections administered in the opposite order. Patients assessed preference, ease of use, and discomfort immediately after the injections and 2 weeks later. Ninety-one patients were included (median age=42.7 years [range, 19.7-93.7]; 58% male). The autoinjector was preferred by 76.9% of patients immediately after injections and by 71.4% 2 weeks later. The autoinjector was more often considered extremely easy or easy to use (94.5%) than the prefilled syringe (73.6%). Moderate discomfort or worse was reported by more patients when using the prefilled syringe (20.9%) than when using the autoinjector (5.5%), ...Continue Reading

Citations

Sep 21, 2019·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Ubaldo J MartinLorin Roskos
May 22, 2020·The Journal of International Medical Research·Rajagopalan Vijayaraghavan
Feb 21, 2021·European Journal of Hospital Pharmacy. Science and Practice·Cristina Martínez-Múgica BarbosaJavier Barbazán Vázquez
Apr 8, 2021·Drug, Healthcare and Patient Safety·Jesús Tornero MolinaNúria Casamira Ruiz
Jun 13, 2021·Expert Opinion on Biological Therapy·Virginia SolitanoSilvio Danese

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