Preference for Cocaine is Represented in the Orbitofrontal Cortex by an Increased Proportion of Cocaine Use-Coding Neurons

Cerebral Cortex
Karine Guillem, Serge H Ahmed

Abstract

Cocaine addiction is a harmful preference for drug use over and at the expense of other nondrug-related activities. Here we identify in the rat orbitofrontal cortex (OFC) a mechanism that explains individual preferences between cocaine use and an alternative, nondrug action. OFC neuronal activity was recorded while rats performed each of these 2 actions separately or while they chose between them. First, we found that these actions are encoded by 2 nonoverlapping neuronal populations and that the relative size of the cocaine population represented individual preferences. A larger relative size was only observed in cocaine-preferring individuals. Second, OFC neurons encoding a given individual's preferred action progressively fired more than other action-coding neurons few seconds before the preferred action was actually chosen, suggesting a prechoice neuronal competition for action selection. In cocaine-preferring rats, this manifested by a prechoice ramping-up activity in favor of the cocaine population. Finally, pharmacological manipulation of prechoice activity in favor of the cocaine population caused nondrug-preferring rats to shift their choice to cocaine. Overall, this study suggests that an individual preference for coc...Continue Reading

References

Jun 28, 1979·Psychopharmacology·D C BalopoleD Dorph
Sep 7, 1989·Nature·W T NewsomeJ A Movshon
May 5, 1999·Nature·L Tremblay, W Schultz
Nov 19, 2003·The European Journal of Neuroscience·Jonathan D Wallis, Earl K Miller
Sep 21, 2004·Nature Reviews. Neuroscience·Henry MarkramCaizhi Wu
Oct 1, 2005·The Journal of Comparative Neurology·Paul L A GabbottSarah J Busby
Nov 29, 2005·Science·Kazuyuki SamejimaMinoru Kimura
Apr 25, 2006·Nature·Camillo Padoa-Schioppa, John A Assad
Aug 4, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Houman Homayoun, Bita Moghaddam
Aug 16, 2006·Neuron·Claudia E FeiersteinZachary F Mainen
Aug 2, 2007·PloS One·Magalie LenoirSerge H Ahmed
Jan 25, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexxai V Kravitz, Laura L Peoples
Feb 6, 2008·Neuroscience Letters·Eduardo A SchilmanHenk J Groenewegen
Jun 12, 2008·Nature Reviews. Neuroscience·Antonio RangelP Read Montague
Jul 30, 2008·The Behavioral and Brain Sciences·A David RedishAdam Johnson
Jul 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Thomas H B FitzGeraldRaymond J Dolan
Sep 25, 2009·Journal of Neurophysiology·Steven W Kennerley, Jonathan D Wallis
Nov 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hoseok KimMin Whan Jung
Apr 14, 2010·The European Journal of Neuroscience·Jamie D Roitman, Mitchell F Roitman
Apr 22, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·James J Young, Matthew L Shapiro
Oct 21, 2011·Nature Reviews. Neuroscience·Rita Z Goldstein, Nora D Volkow
Dec 6, 2011·Trends in Cognitive Sciences·Mohammed R Milad, Scott L Rauch
Feb 24, 2012·The European Journal of Neuroscience·Courtney M Cameron, Regina M Carelli
Aug 9, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kerry A KerstetterTod E Kippin
Jan 29, 2013·Neuron·Masaaki OgawaGeoffrey Schoenbaum
Feb 23, 2013·Current Opinion in Neurobiology·Serge H AhmedKarine Guillem
Jul 16, 2013·Current Protocols in Neuroscience·Magalie LenoirSerge H Ahmed
Mar 8, 2014·Addiction Biology·Heather B Madsen, Serge H Ahmed
Jun 3, 2014·Experimental and Clinical Psychopharmacology·Brendan J TunstallDavid N Kearns
Jun 11, 2014·Addiction·Christopher S MartinKenneth J Sher
Jul 22, 2014·Nature Neuroscience·Federica LucantonioGeoffrey Schoenbaum
Aug 1, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David E Moorman, Gary Aston-Jones
Feb 27, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Makoto Ito, Kenji Doya
May 8, 2015·Current Opinion in Neurobiology·Yaniv Ziv, Kunal K Ghosh
Jul 2, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Youna VandaeleSerge H Ahmed

Citations

Jul 14, 2017·Addiction Biology·Karine GuillemSerge H Ahmed
Sep 10, 2019·Addiction·Christina J Perry, Andrew J Lawrence
Dec 21, 2018·Nature·Vincent PascoliChristian Lüscher
Jan 7, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lee Hogarth
Jul 31, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ludivine CanchySerge H Ahmed
Aug 12, 2020·Nature Communications·Sebastiano BariselliAlexxai V Kravitz
Jun 17, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Amy C Leach, Mark J Ferris
Mar 8, 2019·Translational Psychiatry·Youna VandaeleSerge H Ahmed
Jun 12, 2020·Frontiers in Behavioral Neuroscience·Youna VandaeleSerge H Ahmed
Oct 8, 2020·Nature Reviews. Neuroscience·Marco VenniroYavin Shaham

Related Concepts

Nerve Impulses
Topical anesthetic
Metazoa
Choice Behavior
Cocaine Hydrochloride
Operant Conditioning
Neurons
Reaction Time
Rewards
Saccharin Sodium

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Related Papers

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
A G Polunina, E A Briun
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Jean-François LepageFrançois Champoux
Journal of Neurophysiology
Michael CamposShinsuke Shimojo
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Camillo Padoa-Schioppa
© 2021 Meta ULC. All rights reserved