PMID: 16801Jan 1, 1976Paper

Preference studies of triazolam with standard hypnotics in out-patients with insomnia

The Journal of International Medical Research
L F FabreR T Harris

Abstract

One hundred and four patients suffering from insomnia took part in four different two-night double-blind crossover trials of triazolam. In three separate studies, triazolam 0-5 mg was compared to placebo, flurazepam 30 mg and chloral hydrate 500 mg. Triazolam 0-5 mg was found to be preferred and to be superior to placebo, flurazepam and chloral hydrate in the treatment of insomnia. Analysis of sleep questionnaire data showed triazolam to be superior to the other treatments on the following: How much did the medication help you sleep, onset of sleep, duration of sleep and number of awakenings. Additionally, triazolam was superior to chloral hydrate on the feeling in the morning parameter. In another comparison of triazolam 0-25 mg to flurazepan 15 mg, triazolam was not significantly better than flurazepam on any of the efficacy parameters except that the patients felt more alert the morning following triazolam that following flurazepam. On all efficacy endpoints, trends for all parameters favoured triazolam 0-25 mg over flurazepam 15 mg. Untoward side-effects in these four studies were minimal.

References

Jan 1, 1975·Psychopharmacologia·G VogelK Sexton
Feb 1, 1974·Journal of Clinical Pharmacology·W VeldkampH V Demissianos
Dec 22, 1966·The New England Journal of Medicine·H JickH Muench

Citations

Jan 1, 1980·The Journal of International Medical Research·V PegramP Linton
Jul 1, 1983·Drug Intelligence & Clinical Pharmacy·P D Kroboth, R P Juhl
May 1, 1983·Pharmacotherapy·T RothF Zorick
Mar 7, 2006·Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists·Russell P Rosenberg
Aug 5, 2015·Behavioral Sleep Medicine·Janet M Y CheungBandana Saini

Related Concepts

Noctec
Clinical Trials
Double-Blind Method
Staurodorm
Transient Insomnia
Anti-Anxiety Effect
Trilam

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