Preferential benefit of antibody induction therapy in kidney recipients with high pretransplant frequencies of donor-reactive interferon-gamma enzyme-linked immunosorbent spots.

Transplantation
Joshua J AugustineD E Hricik

Abstract

The decision to use induction antibody therapy in kidney transplantation is often based on perceived patient risk, as no objective biomarker has been shown to predict the effectiveness of such therapy. Because pretransplant T-cell alloreactivity has been shown to increase the risk of poor posttransplant outcome, and because induction therapy is directed at alloreactive T cells, we hypothesized that antibody induction would preferentially benefit patients with high pretransplant antidonor T-cell immunity. In a retrospective analysis of 130 patients who had enrolled in an immune monitoring study, we correlated acute rejection rates, renal allograft function, and use of antibody induction therapy with donor-reactive interferon-gamma enzyme-linked immunosorbent spot (ELISPOT) frequencies assessed pre and postkidney transplantation. Of the 32 ELISPOT (+) patients, eight received induction therapy and had no rejection. Of the remaining 24 ELISPOT (+) patients with no induction therapy, acute rejection occurred in 11 (46%), (P=0.02). Twelve month glomerular filtration rate was significantly higher in the eight patients who received induction therapy (P=0.0001). Posttransplant conversion to a negative ELISPOT assay occurred in 86% of p...Continue Reading

References

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Citations

Aug 8, 2008·Current Opinion in Organ Transplantation·Rajani Dinavahi, Peter S Heeger
Dec 22, 2011·Current Opinion in Organ Transplantation·Paolo Cravedi, Peter S Heeger
Sep 29, 2011·Journal of the American Society of Nephrology : JASN·Adnan SharifRichard Borrows
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Sep 26, 2009·Current Opinion in Organ Transplantation·Birgit SawitzkiHans-Dieter Volk
Oct 9, 2009·International Reviews of Immunology·Volker Daniel, Gerhard Opelz
Feb 18, 2010·Expert Review of Clinical Immunology·Paolo Cravedi, Roslyn B Mannon
Nov 28, 2013·Kidney International·Emilio D Poggio, Joshua J Augustine
Jun 27, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Joshua J Augustine, Donald E Hricik
Jun 12, 2012·Translational Research : the Journal of Laboratory and Clinical Medicine·Yonggoo KimEun-Jee Oh
Aug 19, 2015·Clinical Biochemistry·Elena Crespo, Oriol Bestard
Aug 18, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Aparna PadiyarDonald E Hricik
May 14, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L CherkasskyE D Poggio
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Feb 9, 2010·Tissue Antigens·N L Reinsmoen
Aug 24, 2010·Advances in Chronic Kidney Disease·James N Fleming, Nicole A Weimert
Aug 1, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D E HricikUNKNOWN CTOT-01 consortium
Dec 6, 2014·Transplantation Reviews·Anita MehrotraPaolo Cravedi
Jun 2, 2016·Journal of Nephrology·Oriol Bestard, Paolo Cravedi
Jan 14, 2016·Transplantation·Susan DeWolfMegan Sykes
Jun 20, 2017·The Journal of Clinical Investigation·Susan DeWolf, Megan Sykes
Nov 9, 2010·Cell Transplantation·Christian TosoA M James Shapiro
Jan 1, 2012·Cells·Jennifer R Zitzner, Anat R Tambur
Apr 1, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Chris WiebePeter W Nickerson
Jun 21, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Vikas R Dharnidharka, Andrew Malone
Nov 26, 2009·Transplantation·Rajani Dinavahi, Peter S Heeger
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Dec 7, 2013·Expert Review of Molecular Diagnostics·Xuemei ZhangGary G Xiao
Dec 16, 2021·International Journal of Immunogenetics·Eva GirmanovaAntonij Slavcev

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