Preferential development of neuropeptide Y/GABA circuit in hypothalamic arcuate nucleus in postnatal rats

Brain Research
Xiaoping SunMichael G Ross

Abstract

The hypothalamus, which plays a critical role in regulation of energy homeostasis, is formed during the perinatal period and thus vulnerable to fetal/newborn environmental conditions. We investigated synaptogenesis and neurotransmission of neurons in arcuate nucleus of the hypothalamus (ARH) during the postnatal period using immunohistochemical and electrophysiological methods. Our results show that the density of neuropeptide Y (NPY) fibers increases abruptly after the second postnatal week. NPY and proopiomelanocortin (POMC) immunoreactive fibers/varicosities puncta are mutually juxtaposed to perikarya of both neurons with increasing NPY and decreasing POMC apposition until the third postnatal week. The frequencies of spontaneous GABAergic inhibitory and glutamatergic excitatory postsynaptic currents (sIPSC and sEPSC) increase with age, with action potential dependent sIPSCs predominant during first postnatal week and sEPSCs thereafter. The presynaptic function of ARH synapses appears to reach adult levels around the age of weaning, while the postsynaptic receptors are still undergoing modification, evidenced by changes of frequencies, amplitudes and deactivation kinetics of PSCs. The number of NPY fibers juxtaposed to NPY ne...Continue Reading

References

Dec 22, 1990·The Journal of Comparative Neurology·C Decavel, A N Van den Pol
Sep 5, 2002·Nature Reviews. Neuroscience·David F Owens, Arnold R Kriegstein
Sep 5, 2002·Nature Reviews. Neuroscience·Yehezkel Ben-Ari
Feb 13, 2003·Journal of Neuroscience Methods·Bassam N Hamam, Timothy E Kennedy
Nov 19, 2003·European Journal of Pharmacology·Michael A Cowley
Apr 6, 2004·Science·Sebastien G BouretRichard B Simerly
Apr 6, 2004·Science·Shirly PintoTamas L Horvath
Nov 16, 2004·Trends in Endocrinology and Metabolism : TEM·Erin E JobstMichael A Cowley
Apr 28, 2005·Nature Neuroscience·Roger D Cone
Aug 12, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Claudio Acuna-GoycoleaAnthony N van den Pol
Sep 21, 2005·Nature Neuroscience·Scott M SternsonJeffrey M Friedman
Nov 11, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Claudio Acuna-Goycolea, Anthony N van den Pol
Nov 18, 2005·Physiology & Behavior·Kevin L GroveM Susan Smith
Sep 13, 2006·Clinical Genetics·S G Bouret, R B Simerly
Apr 24, 2007·Cell·Anthony P CollStephen O'Rahilly
Oct 5, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lunbin DengGong Chen
Oct 13, 2007·Regulatory Peptides·Yasunori HoriTakemi Yoshida
Jan 29, 2008·Recent Patents on CNS Drug Discovery·Sara XapelliJoão O Malva
Feb 6, 2008·Cell Metabolism·Sebastien G BouretRichard B Simerly
Apr 5, 2008·Stem Cells·Fabienne AgasseJoão O Malva
Jan 23, 2009·Nature Neuroscience·Qingchun TongBradford B Lowell
Apr 29, 2009·PloS One·Lucas A MongiatAlejandro F Schinder
Oct 30, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shane T HentgesMalcolm J Low
Nov 3, 2009·The European Journal of Neuroscience·Marcelo O Dietrich, Tamas L Horvath
Dec 4, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ying Li, Anthony N van den Pol
Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Tamas L HorvathMatthias H Tschöp
Sep 17, 2010·Journal of Neurophysiology·Sung Kun Chun, Young-Hawn Jo

❮ Previous
Next ❯

Citations

Apr 6, 2017·Neuroscience Letters·Qiang LiuTieqiao Wen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.