Preferential expression of connexin37 and connexin40 in the endothelium of the portal veins during mouse liver development

Cell and Tissue Research
Nobuyoshi ShiojiriToru Koike

Abstract

Hepatic blood vessels consist of the hepatic artery and three types of venous channels (the portal veins, the sinusoids, and the hepatic veins). This study was undertaken to analyze, by immunohistochemistry, connexin expression throughout the vascular development of the fetal mouse liver with special attention being given to portal vein development. In the adult liver, connexin37 and connexin40 were expressed in the endothelium of the portal vein and hepatic artery, but not in those of the hepatic vein and sinusoids. Connexin43 was expressed in mesothelial cells and smooth muscle cells of the portal veins. The preferential expression of connexin37 and connexin40 in portal veins was seen throughout liver development, including its primordium formation stage (10.5-day or 11.5-day stage), although connexin37 expression was transiently seen in free nonparenchymal cells in fetal stages. The differentiation of each blood vessel in the hepatic vascular system may occur in early developmental stages, soon after hepatic primordium formation.

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Citations

Jul 29, 2009·Critical Reviews in Biochemistry and Molecular Biology·Mathieu VinkenVera Rogiers
Sep 7, 2012·Cell Communication & Adhesion·Mathieu VinkenVera Rogiers
Nov 26, 2010·European Journal of Cell Biology·Sachie YamajiMarta Varela-Rey
Mar 5, 2016·Gut and Liver·Ingrid Lua, Kinji Asahina
Dec 7, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mathieu VinkenVera Rogiers
Sep 11, 2010·Microscopy Research and Technique·Bruno CogliatiMaria Lúcia Zaidan Dagli
Nov 18, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yoshinori SugiyamaNobuyoshi Shiojiri
Dec 20, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Manuel Hernández-GuerraEnrique Quintero
Mar 24, 2016·Cell Communication & Adhesion·Joost WillebrordsMathieu Vinken
Mar 21, 2012·Archives of Biochemistry and Biophysics·Rekha KarJean X Jiang
Jun 9, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Michaël MaesMathieu Vinken
Nov 13, 2012·Developmental Biology·Stephanie J MungerAlexander M Simon
Jun 19, 2015·Cellular and Molecular Life Sciences : CMLS·Michaël MaesMathieu Vinken
Nov 2, 2014·Stem Cell Reports·Orit GoldmanValerie Gouon-Evans
Jul 9, 2016·Critical Reviews in Biochemistry and Molecular Biology·Joost WillebrordsMathieu Vinken
Nov 5, 2016·Reproductive Toxicology·John M DeSesso
Jul 18, 2016·Journal of Hepatology·Johanne PoissonPierre-Emmanuel Rautou
Sep 29, 2019·World Journal of Gastroenterology : WJG·Huan LiXiao-Ming Liu
Feb 15, 2021·Translational Research : the Journal of Laboratory and Clinical Medicine·Shlok JindalGopinath Packirisamy

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