PMID: 11335127May 4, 2001Paper

Preferential expression of Mdm2 oncogene during the development of neural crest and its derivatives in mouse early embryogenesis

Mechanisms of Development
S DaujatJ Piette

Abstract

The Mdm2 oncoprotein acts as the principal negative regulator of p53 activities and is essential for its control during mouse early development, at least before implantation. We analyzed Mdm2 expression between 7.5 and 9 days post-coitum (dpc) by whole-mount in situ hybridization and report here a novel expression pattern during neural crest development. At 7.5 dpc Mdm2 becomes preferentially expressed at the top of the neural folds. Between 8 and 9 dpc, this preferential expression is also observed in neural crest cells migrating from the closing brain towards craniofacial regions and the first three branchial arches. It persists in the craniofacial mesenchyme and the first branchial arch in 9 dpc embryos. Migrating neural crest cells in the tail region are also preferentially labeled at this stage. At day 9.5 Mdm2 becomes more ubiquitously expressed throughout the embryo as reported before.

References

Jun 29, 1995·Nature·D HenriqueD Ish-Horowicz
Jul 4, 1998·Mechanisms of Development·T LéveillardB Wasylyk
Apr 25, 2000·Nucleic Acids Research·E BasyukL Journot

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Citations

Jul 23, 2011·Genes & Cancer·Susan M MendrysaReem Malek
Aug 23, 2012·Archives of Biochemistry and Biophysics·E A Ostrakhovitch, O A Semenikhin
Oct 12, 2010·Cancer Biology & Therapy·Abhinav K Jain, Michelle Craig Barton
Oct 3, 2003·Nature Reviews. Neuroscience·Laura S Gammill, Marianne Bronner-Fraser
Apr 22, 2020·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Marie-Claude BeauchampLoydie Anne Jerome-Majewska

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