PMID: 7541370Dec 1, 1994Paper

Preferential expression of the cell adhesion molecule CD44 in papillary thyroid carcinoma

Experimental and Molecular Pathology
J FiggeG Bratslavsky

Abstract

CD44 is a polymorphic family of immunologically related integral membrane glycoproteins associated with cell matrix adhesion, lymphocyte activation and targeting, and tumor growth and metastasis. We studied CD44 expression in 114 formalin-fixed paraffin-embedded thyroid tumors using the A3D8 anti-human CD44 monoclonal antibody. Sixty-five of 67 papillary carcinomas (97%) strongly expressed CD44 with an intense plasma membrane pattern. Thirty-seven of these cases originated from Albany, New York, and 30 cases from Russia. Immunoreactivity was also observed in 9 of 16 follicular adenomas (56%); 4 of 8 Hurthle cell neoplasms (50%); 5 of 15 medullary carcinomas (33%); and 3 of 8 follicular carcinomas (38%). These results show that among thyroid neoplasms, papillary carcinomas preferentially display the CD44 antigen (P < or = 0.001). Nonneoplastic follicular epithelium exhibited a low to moderate level of staining. To further characterize the CD44 isoform, we tested a subset of cases with the 2F10 anti-human CD44 variant 6 monoclonal antibody, which recognizes a CD44 variant exon (CD44v6) implicated in tumor metastasis. Eleven of 11 papillary carcinomas tested were 2F10 positive, and 1 of the follicular carcinomas was positive. Thes...Continue Reading

Citations

Dec 31, 2014·Archives of Pathology & Laboratory Medicine·Haiyan Liu, Fan Lin
Feb 6, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Marc-André FortinHans Lundqvist
Aug 6, 2005·Applied Immunohistochemistry & Molecular Morphology : AIMM·Sherif Rezk, Ashraf Khan
Dec 19, 2015·Cancer Control : Journal of the Moffitt Cancer Center·Zhenzhen LinYan Li
Apr 22, 1997·International Journal of Cancer. Journal International Du Cancer·P SpeiserC Kainz
Apr 1, 1997·Molecular Pathology : MP·Z Rudzki, S Jothy
Dec 1, 1996·Histochemistry and Cell Biology·P KomminothJ Roth
Nov 4, 2004·Clinical Endocrinology·Jörg Bojunga, Stefan Zeuzem
Dec 1, 1996·Japanese Journal of Cancer Research : Gann·T TakanoN Amino
Mar 6, 2008·Archives of Pathology & Laboratory Medicine·Sandra Fischer, Sylvia L Asa

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