Preferential expression of the gene for a putative inositol 1,4,5-trisphosphate receptor homologue in the mushroom bodies of the brain of the worker honeybee Apis mellifera L

Biochemical and Biophysical Research Communications
A KamikouchiT Kubo

Abstract

A gene expressed preferentially in the mushroom bodies of the brain of the worker honeybee Apis mellifera L. was identified by the differential display method and its cDNA was isolated. The cDNA fragment of 534 bp (clone A1) contained an open reading frame encoding 177 amino acid residues having 78, 72, 70, 59 and 55% sequence identities with the inositol 1,4,5-trisphosphate (IP3) receptors of Drosophila melanogaster, Xenopus laevis and humans (types 1, 2 and 3), respectively, suggesting that it encodes a putative IP3 receptor homologue of the honeybee. In situ hybridization revealed that the gene encoding clone A1 was expressed preferentially in the mushroom bodies and not in the optic lobes, antennal lobes and central bodies; in the mushroom body, it was expressed strongly in the large type Kenyon cells and weakly in the small type Kenyon cells. Reverse transcription polymerase chain reaction analysis showed that the gene was expressed strongly in the head and weakly in the antennae, legs, thorax, and abdomen. These results suggest that the A1 gene product plays a crucial role in neural transmission in the mushroom bodies of the worker bee brain.

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Citations

Jan 15, 2004·Journal of Virology·Tomoko FujiyukiTakeo Kubo
Sep 15, 2006·Proceedings of the National Academy of Sciences of the United States of America·Masatomo KobayashiKatsuo Furukubo-Tokunaga
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·T MiuraT Matsumoto
Jul 2, 2011·Journal of Insect Physiology·Luciana Karen CalábriaFoued Salmen Espindola
Jan 27, 2017·International Journal of Molecular Sciences·Seika Takayanagi-KiyaTakeo Kubo
Sep 24, 1999·The Journal of Comparative Neurology·S M FarrisS E Fahrbach
Nov 6, 2018·Pest Management Science·Aline F CataeThaisa C Roat
Jan 21, 2006·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Sayaka HoriTakeo Kubo
Dec 12, 2012·Archives of Environmental Contamination and Toxicology·Thaisa Cristina RoatOsmar Malaspina
Sep 3, 2020·Science Advances·Lihong ShengRoberto Bonasio
Sep 28, 2002·The Journal of Comparative Neurology·Jordane MalaterreMyriam Cayre
Sep 17, 2020·Science Advances·Lihong ShengRoberto Bonasio
Feb 11, 2000·Cell Calcium·C W TaylorS A Morris
Apr 28, 2004·Biochemical and Biophysical Research Communications·Takekazu Kunieda, Takeo Kubo

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