PMID: 8880897Aug 1, 1996Paper

Preferential formation of 13-hydroxylinoleic acid by human peripheral blood eosinophils

F EngelsF P Nijkamp


Lipid mediators released by inflammatory and immune cells play an important role in inflammatory and immune processes. Most attention has been focussed on arachidonic-derived mediators, including prostaglandins, thromboxanes, leukotrienes, and lipoxins. Literature data, however, suggest that also metabolites of the unsaturated fatty acid linoleic acid may be important in this respect. We have studied the formation and release of 9-hydroxy- and 13-hydroxy-linoleic acid (9-HODE and 13-HODE) by enriched populations of human peripheral blood neutrophils, eosinophils, basophils, monocytes, and lymphocytes. We demonstrate that the eosinophil preferentially produces 13-HODE, whereas the other cell types produce equal amounts of 9-HODE and 13-HODE. The biological significance of these findings is discussed.


May 17, 1991·European Journal of Pharmacology·P A HenricksF P Nijkamp
Jun 15, 1989·Biochemical and Biophysical Research Communications·O ReinaudD Mansuy
Sep 4, 1987·Biochimica Et Biophysica Acta·D H Nugteren, G A Kivits
Sep 25, 1987·Biochimica Et Biophysica Acta·P WalstraJ F Vliegenthart
Mar 12, 1984·FEBS Letters·J VerhagenJ F Vliegenthart
Sep 1, 1994·Immunology Letters·A BruniC Chizzolini
Jul 1, 1995·The Journal of Allergy and Clinical Immunology·P A HenricksF P Nijkamp
Apr 1, 1994·The European Respiratory Journal·C KroegelH Matthys
Mar 1, 1994·The European Respiratory Journal·C KroegelJ A Warner

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