Preferential HLA-B27 Allorecognition Displayed by Multiple Cross-Reactive Antiviral CD8+ T Cell Receptors.

Frontiers in Immunology
Louise C RowntreeNicole A Mifsud

Abstract

T cells provide essential immunosurveillance to combat and eliminate infection from pathogens, yet these cells can also induce unwanted immune responses via T cell receptor (TCR) cross-reactivity, also known as heterologous immunity. Indeed, pathogen-induced TCR cross-reactivity has shown to be a common, robust, and functionally potent mechanism that can trigger a spectrum of human immunopathologies associated with either transplant rejection, drug allergy, and autoimmunity. Here, we report that several virus-specific CD8+ T cells directed against peptides derived from chronic viruses (EBV, CMV, and HIV-1) presented by high frequency HLA-A and -B allomorphs differentially cross-react toward HLA-B27 allotypes in a highly focused and hierarchical manner. Given the commonality of cross-reactive T cells and their potential contribution to adverse outcomes in allogeneic transplants, our study demonstrates that multiple antiviral T cells recognizing the same HLA allomorph could pose an extra layer of complexity for organ matching.

References

Dec 27, 1990·The New England Journal of Medicine·K FleischhauerS Y Yang
Oct 15, 1993·Science·E PadovanA Lanzavecchia
Apr 24, 2002·Immunity·Anthony P WilliamsTim Elliott
Feb 4, 2003·Nature Immunology·Jean-Baptiste ReiserBernard Malissen
Nov 18, 2003·Immunological Reviews·Andrew B AdamsChristian P Larsen
Mar 24, 2004·Molecular Immunology·Darcy B WilsonK Christopher Garcia
Jul 1, 2004·The Journal of Experimental Medicine·Danielle ZernichJames McCluskey
Dec 21, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·N A MifsudJ McCluskey
Oct 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lindsay L JonesDavid M Kranz
Jan 13, 2010·Immunity·Whitney A MacdonaldJames McCluskey
Feb 18, 2010·Blood·Avital L AmirMirjam H M Heemskerk
Mar 3, 2010·Immunology and Cell Biology·Thi H O NguyenNicole A Mifsud
Jan 19, 2011·Transplantation·Lloyd J A D'OrsognaFrans H J Claas
Feb 2, 2011·Transplantation·Lloyd J A D'OrsognaFrans H J Claas
Aug 23, 2011·Seminars in Respiratory and Critical Care Medicine·Martin R Zamora
Nov 22, 2011·The Journal of Biological Chemistry·Linda WooldridgeAndrew K Sewell
Jun 23, 2012·Nature·Patricia T IllingJames McCluskey
Apr 30, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thi H O NguyenNicole A Mifsud
Jun 24, 2014·Nature Biotechnology·Arnold HanMark M Davis
Nov 12, 2015·Current Opinion in Organ Transplantation·Amritha Balakrishnan, Gerald P Morris
Jan 11, 2016·Arthritis & Rheumatology·Bernhard LollAndreas Ziegler
Apr 5, 2017·Cellular Immunology·Coral-Ann AlmeidaLloyd J D'Orsogna
Dec 13, 2017·The Journal of Biological Chemistry·Preeti Sharma, David M Kranz
May 8, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Louise C RowntreeNicole A Mifsud
May 19, 2019·The Journal of Allergy and Clinical Immunology·Coral-Ann AlmeidaLloyd J D'Orsogna
May 28, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Lloyd J D'OrsognaFrans H J Claas

❮ Previous
Next ❯

Methods Mentioned

BETA
density gradient centrifugation
FCS
flow cytometry
Assay
PCR

Software Mentioned

GraphPad
FlowJo
Prism

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
Louise C RowntreeNicole A Mifsud
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
K M HeutinckI J M Ten Berge
© 2021 Meta ULC. All rights reserved