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Preferential hydrophobic interactions are responsible for a preference of D-amino acids in the aminoacylation of 5'-AMP with hydrophobic amino acids

Experientia

Apr 25, 1992

J C LaceyR S Sabatini

Abstract

We have studied the chemistry of aminoacyl AMP to model reactions at the 3' terminus of aminoacyl tRNA for the purpose of understanding the origin of protein synthesis. The present studies relate to the D, L preference in the esterification of 5'-AMP. All N-acetyl amino acids we studied...read more

Mentioned in this Paper

Aminoacylation
Molecular Stereochemistry
RNA, Transfer, Amino Acyl
Structure-Activity Relationship
Organic solvent product
Amino Acid [EPC]
Amino Acids, I.V. solution additive
Antifibrinolytic amino acids
5'-Adenylic Acid
Protein Biosynthesis
Paper Details
References
  • References20
  • Citations4
12

Preferential hydrophobic interactions are responsible for a preference of D-amino acids in the aminoacylation of 5'-AMP with hydrophobic amino acids

Experientia

Apr 25, 1992

J C LaceyR S Sabatini

PMID: 1582495

DOI: 10.1007/bf01923434

Abstract

We have studied the chemistry of aminoacyl AMP to model reactions at the 3' terminus of aminoacyl tRNA for the purpose of understanding the origin of protein synthesis. The present studies relate to the D, L preference in the esterification of 5'-AMP. All N-acetyl amino acids we studied...read more

Mentioned in this Paper

Aminoacylation
Molecular Stereochemistry
RNA, Transfer, Amino Acyl
Structure-Activity Relationship
Organic solvent product
Amino Acid [EPC]
Amino Acids, I.V. solution additive
Antifibrinolytic amino acids
5'-Adenylic Acid
Protein Biosynthesis

Related Papers

Paper Details
References
  • References20
  • Citations4
12
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