May 21, 2008

Preferential in situ CD4+CD56+ T cell activation and expansion within human glioblastoma

The Journal of Immunology : Official Journal of the American Association of Immunologists
Allen WaziriJeffrey N Bruce

Abstract

Recent evidence suggests that suppression of the cellular immune response is often attributable to populations of functionally distinct T cells that act to down-regulate Ag-specific effector T cells. Using flow cytometry, we evaluated tumor-infiltrating lymphocytes (TIL) from patients undergoing neurosurgical resection of glioblastoma multiforme (GBM), metastatic lung carcinoma, and meningioma for markers known to be expressed on immunoregulatory T cells. Ex vivo phenotypic characteristics, cellular proliferation, and cytokine expression patterns were compared between T cell subsets found in the PBMC and within TIL from fresh tumor samples. Interestingly, nearly half of all T cells infiltrating GBM specimens were CD56(+) T cells, while much smaller percentages of similar cells were identified within metastatic lung tumors and meningiomas. CD56(+) T cells identified within GBM were not canonical, or "invariant," NKT cells, as they demonstrated diverse TCR expression, a primarily CD4 single-positive phenotype, and lack of CD1d reactivity. The percentage of CD56(+) T cells exhibiting evidence of proliferation within GBM was 3- to 4-fold higher than the proportion of proliferating CD56(-) T cells from these lesions. In addition, di...Continue Reading

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Mentioned in this Paper

Glioblastoma Multiforme
Neuro-Oncological Ventral Antigen 2
Establishment and Maintenance of Localization
Tumor Cells, Uncertain Whether Benign or Malignant
Immune Response
Flow Cytometry
CD1D gene
Tumor Immunity
Dermatofibrosarcoma Protuberans
T-Lymphocyte

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