Preferential infection of immature dendritic cells and B cells by mouse mammary tumor virus

The Journal of Immunology : Official Journal of the American Association of Immunologists
S VacheronH Acha-Orbea

Abstract

Until now it was thought that the retrovirus mouse mammary tumor virus preferentially infects B cells, which thereafter proliferate and differentiate due to superantigen-mediated T cell help. We describe in this study that dendritic cells are infectable at levels comparable to B cells in the first days after virus injection. Moreover, IgM knockout mice have chronically deleted superantigen-reactive T cells after MMTV injection, indicating that superantigen presentation by dendritic cells is sufficient for T cell deletion. In both subsets initially only few cells were infected, but there was an exponential increase in numbers of infected B cells due to superantigen-mediated T cell help, explaining that at the peak of the response infection is almost exclusively found in B cells. The level of infection in vivo was below 1 in 1000 dendritic cells or B cells. Infection levels in freshly isolated dendritic cells from spleen, Langerhans cells from skin, or bone marrow-derived dendritic cells were compared in an in vitro infection assay. Immature dendritic cells such as Langerhans cells or bone marrow-derived dendritic cells were infected 10- to 30-fold more efficiently than mature splenic dendritic cells. Bone marrow-derived dendriti...Continue Reading

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Citations

Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Georges A AzarJacques Thibodeau
Jul 29, 2008·Journal of Mammary Gland Biology and Neoplasia·Susan R Ross
Jan 21, 2009·Journal of Virology·Chioma M OkeomaSusan R Ross
Mar 31, 2009·International Journal of Cancer. Journal International Du Cancer·Harald zur Hausen
Feb 3, 2007·Journal of Virology·Maria Cecilia CourregesSusan R Ross
Nov 16, 2007·Journal of Virology·Chioma M OkeomaSusan R Ross
Dec 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Daniela FinkeHans Acha-Orbea
Dec 25, 2003·Journal of Virology·Dalia BurzynIsabel Piazzon
May 20, 2006·The Journal of Pathology·F ZammarchiG Bevilacqua

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