PMID: 2106002Feb 1, 1990Paper

Preferential linkage of bcl-2 to immunoglobulin light chain gene in chronic lymphocytic leukemia

The Journal of Experimental Medicine
M AdachiY Tsujimoto

Abstract

Most of human follicular lymphomas possess the t(14;18) chromosome translocation that juxtaposes the IgH gene to the 3' region of bcl-2 in a head-to-tail configuration. Here we show that the rearrangement of the bcl-2 gene occurs in a significant fraction (approximately of 10%) of B cell CLL. In all cases analyzed, breakpoints on chromosome 18 clustered at the 5' flanking region of the bcl-2 gene, and no rearrangements were found at the major or minor breakpoint clustering region (3' region of bcl-2 gene) typical of the t(14;18) chromosome translocation. All of the rearranged bcl-2 genes were juxtaposed with the Ig lambda or K genes in a head-to-head configuration. These results imply that the bcl-2 gene is preferentially linked to the IgL genes in CLL and could function in leukemogenesis.

References

Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M AdachiY Tsujimoto
Jul 1, 1986·The Journal of Experimental Medicine·M L ClearyJ Sklar
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·Y Tsujimoto, C M Croce
Jan 8, 1987·The New England Journal of Medicine·J J YunisM Arnesen
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·Y TsujimotoC M Croce
Nov 5, 1987·The New England Journal of Medicine·L M WeissM L Cleary
Jun 21, 1985·Science·Y TsujimotoC M Croce

❮ Previous
Next ❯

Citations

Jun 17, 1998·International Journal of Cancer. Journal International Du Cancer·N Laytragoon-LewinG Klein
Sep 1, 1991·Genes, Chromosomes & Cancer·E LundgrenJ Lind
Mar 1, 1992·Genes, Chromosomes & Cancer·C A GriffinR Mann
Aug 1, 1993·Cancer Genetics and Cytogenetics·P E Crossen, M J Morrison
Apr 1, 1994·Cancer Genetics and Cytogenetics·A AmielM Ravid
Jun 9, 2001·Mutation Research·L MüllauerA Chott
Jun 6, 2009·Cell Death and Differentiation·R I AqeilanC M Croce
May 1, 1994·Bio/technology·P J Barr, L D Tomei
Oct 25, 2006·Nature Reviews. Cancer·George A Calin, Carlo M Croce
Sep 19, 2009·Nature Reviews. Genetics·Carlo M Croce
Oct 10, 2006·Oncogene·G A Calin, C M Croce
Aug 7, 2001·Reviews in Clinical and Experimental Hematology·S StilgenbauerH Döhner
Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A StrasserA W Harris
Oct 1, 1993·The Journal of Experimental Medicine·A RolinkF Melchers
May 6, 2004·Journal of the National Cancer Institute·Shinichi Kitada, John C Reed
Feb 25, 2000·Current Opinion in Oncology·R Bannerji, J C Byrd
Jun 10, 2008·Current Opinion in Hematology·Ramiro Garzon, Carlo M Croce
May 1, 1991·British Journal of Haematology·M F BerthéasJ P Magaud
Aug 1, 1992·British Journal of Haematology·P JonveauxR Berger
Aug 1, 1996·Clinical Molecular Pathology·C D Fegan, F E Davies
Mar 1, 1992·The Journal of Clinical Investigation·H ChangM D Minden
Aug 3, 2007·The Journal of Clinical Investigation·George A Calin, Carlo M Croce
Apr 19, 2013·The Journal of Veterinary Medical Science·Mohammad Monir TawfeeqHisashi Inokuma
Sep 30, 2005·American Journal of Clinical Pathology·Richard R EinersonEllen D Remstein
Sep 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·Amelia CimminoCarlo M Croce
Jun 28, 2014·Cell Death and Differentiation·Y Pekarsky, C M Croce
Oct 1, 1992·Leukemia & Lymphoma·M F BertheasC P Brizard
Oct 1, 1993·Leukemia & Lymphoma·M SchenaF Caligaris-Cappio
Oct 1, 1996·Leukemia & Lymphoma·A BegleiterJ B Johnston
Mar 15, 2006·Critical Reviews in Clinical Laboratory Sciences·Hellinida Thomadaki, Andreas Scorilas
Jan 23, 2009·Leukemia & Lymphoma·Muller FabbriGeorge A Calin
Aug 26, 1998·Leukemia & Lymphoma·M AdachiK Imai
Sep 19, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Giacoma De TullioAttilio Guarini
Jan 31, 2015·International Journal of Molecular Sciences·Jean L KoffLeon Bernal-Mizrachi
Oct 1, 1996·Leukemia & Lymphoma·W PlunkettJ C Reed
Aug 25, 2009·Best Practice & Research. Clinical Haematology·Guido MarcucciCarlo M Croce

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.