Preferential microglial activation associated with pathological alpha synuclein transmission.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Young Eun KimBeomseok Jeon

Abstract

Self-proliferation of the pathological form of α-synuclein was identified as one of the main pathophysiological presentations of Parkinson's disease (PD) a decade ago. Although inflammation has also been suggested to contribute to PD pathogenesis, it is unclear whether this is associated with the pathological spread of α-synuclein aggregation. Herein, we evaluated two main neuroinflammatory processes in the striatum-microgliosis and astrogliosis-after the injection of preformed fibrils of α-synuclein into the mouse striatum. Thus, our study demonstrated that microgliosis accompanied α-synuclein propagation, while astrogliosis did not. Therefore, we report a preferential association between microglia and the process of α-synuclein proliferation.

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Citations

Feb 14, 2021·Journal of Parkinson's Disease·Sonia GeorgePatrik Brundin

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