PMID: 9166757Jun 1, 1997Paper

Preferential potentiation of the effects of serotonin uptake inhibitors by 5-HT1A receptor antagonists in the dorsal raphe pathway: role of somatodendritic autoreceptors

Journal of Neurochemistry
L Romero, F Artigas

Abstract

5-HT1A autoreceptor antagonists enhance the effects of antidepressants by preventing a negative feedback of serotonin (5-HT) at somatodendritic level. The maximal elevations of extracellular concentration of 5-HT (5-HT(ext)) induced by the 5-HT uptake inhibitor paroxetine in forebrain were potentiated by the 5-HT1A antagonist WAY-100635 (1 mg/kg s.c.) in a regionally dependent manner (striatum > frontal cortex > dorsal hippocampus). Paroxetine (3 mg/kg s.c.) decreased forebrain 5-HT(ext) during local blockade of uptake. This reduction was greater in striatum and frontal cortex than in dorsal hippocampus and was counteracted by the local and systemic administration of WAY-100635. The perfusion of 50 micromol/L citalopram in the dorsal or median raphe nucleus reduced 5-HT(ext) in frontal cortex or dorsal hippocampus to 40 and 65% of baseline, respectively. The reduction of cortical 5-HT(ext) induced by perfusion of citalopram in midbrain raphe was fully reversed by WAY-100635 (1 mg/kg s.c.). Together, these data suggest that dorsal raphe neurons projecting to striatum and frontal cortex are more sensitive to self-inhibition mediated by 5-HT1A autoreceptors than median raphe neurons projecting to the hippocampus. Therefore, potent...Continue Reading

Citations

Jul 13, 2000·Journal of Psychopharmacology·R Tao, S B Auerbach
Sep 4, 2012·Journal of Applied Genetics·Dimitry A ChistiakovVladimir P Chekhonin
Jan 20, 2017·Journal of the Royal Society, Interface·Alok JoshiKongFatt Wong-Lin
Aug 5, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sudhakar SelvarajOliver Howes
Jul 31, 2007·Acta Neurologica Scandinavica·M MøllerA Gjedde
Mar 11, 2004·Journal of Neurochemistry·Analía BortolozziAlbert Adell
Mar 12, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Luz RomeroFrancesc Artigas
Jul 13, 2000·Journal of Psychopharmacology·S HjorthS B Auerbach
Aug 13, 2010·The International Journal of Neuropsychopharmacology·Mercè MasanaFrancesc Artigas
Jan 29, 2013·The International Journal of Neuropsychopharmacology·Magdalena NordLars Farde

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