Preferential prescribing and utilization trends of diabetes medications among patients with renal impairment: Emerging role of linagliptin and other dipeptidyl peptidase 4 inhibitors

Endocrinology, Diabetes & Metabolism
Elisabetta PatornoSebastian Schneeweiss

Abstract

Although many newer diabetes medications have become available in the last decade, most have not been widely studied in populations with chronic kidney disease under routine care. Linagliptin, a recently marketed dipeptidyl peptidase 4 (DPP-4) inhibitor, is the only agent in the U.S. that does not require dose adjustment in patients with diabetes mellitus type 2 (T2DM) and renal impairment. We sought to describe baseline kidney function and other key characteristics among patients with diabetes mellitus type 2 (T2DM) initiating linagliptin and other diabetes medications, and to explore prescribing patterns among T2DM patients with moderate to severe renal impairment before and after the launch of linagliptin. Using a population-based cohort study design nested in a large U.S. commercial healthcare dataset linked to laboratory values, we described characteristics of T2DM patients initiating linagliptin and other diabetes medications between May 2011 (launch of linagliptin) and September 2015. We also explored prescribing trends among T2DM patients with moderate to severe renal impairment (ICD-9 diagnosis code 585.3x-6x) who initiated linagliptin and other diabetes medications between January 2006 to September 2015 (before and af...Continue Reading

References

Aug 23, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Wolfgang C WinkelmayerDaniel H Solomon
Sep 25, 2014·Diabetes Care·Katherine R TuttleMark E Molitch

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Citations

Jan 23, 2019·Journal of Diabetes Investigation·Soulmaz Fazeli FarsaniDorothee B Bartels
Jul 30, 2018·BMJ Open·Samantha WilkinsonLaurie Tomlinson
May 29, 2020·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Byron J HoogwerfPranav Gandhi

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