Preferential recognition of human myocardial antigens by T lymphocytes from rheumatic heart disease patients.

Infection and Immunity
M El-DemellawyM Kotb

Abstract

Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) are autoimmune sequelae of upper respiratory infections with group A streptococci (GAS). To gain a better understanding of the pathogenesis of these diseases, we examined the in vitro proliferative responses of peripheral blood mononuclear cells (PBMC) from RHD patients to human myocardial proteins in a T-cell Western assay. A number of myocardial proteins fractionated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis were recognized by PBMC from both patients and controls. However, PBMC from a significant percentage of RHD patients (40%) responded to a discrete band of myocardial proteins migrating with an apparent molecular mass of 50 to 54 kDa while none of the control subject PBMC responded to this protein band (P < or = 0.0001). To further investigate the link between infections with GAS and autoimmune carditis, we studied the proliferative responses of PBMC from patients and controls to myocardial proteins before and after in vitro stimulation of the cells with opsonized GAS isolated from ARF patients. Priming of PBMC with rheumatogenic GAS caused the percentage of RHD patients responding to the 50- to 54-kDa myocardial proteins to increase from 43 t...Continue Reading

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Citations

Aug 31, 2006·The Pediatric Infectious Disease Journal·Thomas B MartinsHarry R Hill
Jun 11, 2003·European Journal of Clinical Investigation·C J LimasD V Cokkinos
Sep 19, 2014·Clinical Medicine Insights. Cardiology·Carlo de Oliveira MartinsEdecio Cunha-Neto
May 21, 2011·Clinical Reviews in Allergy & Immunology·Christopher Chang
Jul 25, 2000·Clinical Microbiology Reviews·M W Cunningham

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