PMID: 9184632Jun 1, 1997Paper

Preferential recognition of synthetic peptides from HTLV-I gp21 envelope protein by HLA-DRB1 alleles associated with HAM/TSP (HTLV-I-associated myelopathy/tropical spastic paraparesis)

Journal of Neuroimmunology
Y YamanoS Sonoda

Abstract

To determine CD4+ T-cell epitopes of HTLV-I-envelope protein recognized by the HLA alleles associated with HAM/TSP, we established 20 CD4+ T-cell lines from peripheral blood mononuclear cells (PBMCs) of naive healthy donors using a panel of synthetic peptides spanning the entire length of HTLV-I-envelope proteins, gp46 and gp21. We quantitated the precursor frequencies of HTLV-1-envelope specific CD4+ T-cells and analyzed epitope specificity in the context of HLA alleles. The precursor frequencies ranged from 3.0 to 10.6 per 10(7) PBMCs in the naive healthy donors. The CD4+ T-cell epitopes of HTLV-I-envelope protein were clustered in amino acids 76 to 90, 136 to 160, 171 to 185 and 196 to 210 of gp46, and in amino acids 366 to 400 and 436 to 485 of gp21. The CD4+ T-cell epitopes of gp21 were preferentially recognized by HLA-DRB1 0101 and 1502 which were known to be associated with HAM/TSP. Thus, it was suggested that HTLV-I gp21 might contain the major CD4+ T-cell epitopes recognized by HLA-DRB1 alleles of HAM/TSP.

References

Dec 1, 1992·Annals of Internal Medicine·A Gessain, O Gout
Aug 1, 1991·Tissue Antigens·M OtaH Inoko
Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·P HoralA Vahlne
Dec 1, 1990·Journal of Neurology, Neurosurgery, and Psychiatry·S IjichiM Osame
Dec 1, 1988·Journal of Neuroimmunology·B KitzeH Wekerle
May 3, 1986·Lancet·M OsameM Tara
Jul 12, 1986·Lancet·C BartholomewW Blattner
Jan 1, 1988·Annals of Neurology·M MoriK Kinoshita
Aug 1, 1985·The Journal of Clinical Investigation·T UchiyamaH Uchino
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M SeikiM Yoshida
Jan 1, 1995·Immunogenetics·G FutakiM Katagiri
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·S HaraguchiN K Day
Jan 1, 1995·Immunogenetics·H G RammenseeS Stevanoviíc
Jul 1, 1993·Journal of Neuropathology and Experimental Neurology·F UmeharaM Osame
Jan 1, 1996·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·S SonodaS Yashiki
Oct 1, 1996·Acta Neurologica Scandinavica·B KitzeS Sonoda

❮ Previous
Next ❯

Citations

Jul 10, 2013·Journal of Neurology·Ana TreviñoVincent Soriano
Jul 19, 2000·Current Opinion in Immunology·C R Bangham
Jun 19, 2014·The Journal of Biological Chemistry·Elizabeth JaworskiFatah Kashanchi
Mar 12, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yotaro TamaiMari Kannagi
Jun 4, 2019·Frontiers in Microbiology·Mineki Saito
Oct 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hiroya KobayashiEsteban Celis
Jun 5, 1999·Microbiology and Molecular Biology Reviews : MMBR·P Höllsberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.