Preferential reduction of quadriceps over respiratory muscle strength and bulk after lung transplantation for cystic fibrosis

Thorax
Christophe PinetMarc Estenne

Abstract

In the absence of complications, recipients of lung transplants for cystic fibrosis have normal pulmonary function but the impact of the procedure on the strength and bulk of respiratory and limb muscles has not been studied. Twelve stable patients who had undergone lung transplantation for cystic fibrosis 48 months earlier (range 8-95) and 12 normal subjects matched for age, height, and sex were studied. The following parameters were measured: standard lung function, peak oxygen uptake by cycle ergometry, diaphragm surface area by computed tomographic (CT) scanning, diaphragm and abdominal muscle thickness by ultrasonography, twitch transdiaphragmatic and gastric pressures, quadriceps isokinetic strength, and quadriceps cross section by CT scanning, and lean body mass. Diaphragm mass was computed from diaphragm surface area and thickness. Twitch transdiaphragmatic and gastric pressures, diaphragm mass, and abdominal muscle thickness were similar in the two groups but quadriceps strength and cross section were decreased by nearly 30% in the patients. Patients had preserved quadriceps strength per unit cross section but reduced quadriceps cross section per unit lean body mass. The cumulative dose of corticosteroids was an indepe...Continue Reading

Associated Clinical Trials

Jul 25, 2017·Marcio Vinicius Fagundes Donadio

References

Sep 26, 1991·The New England Journal of Medicine·T SimilowskiF Bellemare
Jan 1, 1990·The American Review of Respiratory Disease·C PicadoA Agusti-Vidal
Aug 1, 1985·The Journal of Allergy and Clinical Immunology·S L BowyerJ R Hollister
Dec 1, 1984·Respiration Physiology·F Bellemare, B Bigland-Ritchie
May 1, 1995·American Journal of Respiratory and Critical Care Medicine·J G MercierG A Brooks
Jun 1, 1995·American Journal of Respiratory and Critical Care Medicine·J F HokansonG A Brooks
Jul 1, 1994·American Journal of Respiratory and Critical Care Medicine·M DecramerP Rogiers
Apr 1, 1993·The American Review of Respiratory Disease·L C LandsN L Jones
Jun 1, 1996·American Journal of Respiratory and Critical Care Medicine·M DecramerR Dom
Feb 1, 1997·American Journal of Respiratory and Critical Care Medicine·A B EvansD M Systrom
Aug 1, 1997·American Journal of Respiratory and Critical Care Medicine·M CassartM Estenne
Aug 12, 1998·American Journal of Respiratory and Critical Care Medicine·S BernardF Maltais
Mar 2, 1999·American Journal of Respiratory and Critical Care Medicine·K de MeerJ van Der Laag
Apr 8, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·L C LandsR Gauthier
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·X N WangM F Carey
Oct 6, 1999·American Journal of Respiratory and Critical Care Medicine·J G PantojaM B Reid
Nov 11, 1999·American Journal of Respiratory and Critical Care Medicine·G H MillsM Green
Nov 24, 1999·Muscle & Nerve·M Breil, P Chariot
Dec 22, 1999·The European Respiratory Journal·J L VachiéryM Estenne
Mar 11, 2000·American Journal of Respiratory and Critical Care Medicine·M EstenneA De Troyer
Apr 25, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·A C KriegerS Kesten
Oct 12, 2000·The European Respiratory Journal·C Pinet, M Estenne
Nov 9, 2000·American Journal of Respiratory and Critical Care Medicine·C MoserD M Cooper
Mar 19, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Marc EstenneSamuel Yousem
Sep 26, 2002·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·T M EganB S Mueller
Jun 17, 2003·Journal of Applied Physiology·Sinead C Barry, Charles G Gallagher
Jun 25, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Elbert P TrulockMarshall I Hertz
Jun 28, 2003·American Journal of Respiratory and Critical Care Medicine·Christophe PinetMarc Estenne
Oct 7, 2004·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·J HusseyP Greally

❮ Previous
Next ❯

Citations

Oct 12, 2005·Current Opinion in Pulmonary Medicine·David M Orenstein, Linda W Higgins
Oct 17, 2013·American Journal of Respiratory and Critical Care Medicine·Martijn A SpruitUNKNOWN ATS/ERS Task Force on Pulmonary Rehabilitation
Jul 22, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Dmitry RozenbergSunita Mathur
Oct 17, 2012·Paediatric Respiratory Reviews·Athari Almajed, Larry C Lands
Jun 2, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Daniel LangerThierry Troosters
Nov 21, 2008·Revue de pneumologie clinique·C KarilaA Denjean
Mar 7, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D LangerR Gosselink
Jul 3, 2013·Clinical Transplantation·James R WalshPeter M A Hopkins
Jan 6, 2010·The Physician and Sportsmedicine·Sunita MathurRobert D Levy
Feb 22, 2011·Respiratory Physiology & Neurobiology·Isabelle VivodtzevBernard Wuyam
Apr 3, 2007·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Stephanie EnrightDennis J Shale
Jan 10, 2012·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Jason WieboldtNicholas S Hopkinson
Mar 26, 2014·Paediatric Respiratory Reviews·Theodore Dassios
Apr 11, 2009·Journal of Applied Physiology·Marc Estenne
May 7, 2021·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Kenneth WuSunita Mathur
Jun 15, 2021·Indian Journal of Thoracic and Cardiovascular Surgery : Official Organ, Association of Thoracic and Cardiovascular Surgeons of India·Vanessa SoetantoHarpreet Singh Grewal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Respiratory and Critical Care Medicine
Christophe PinetMarc Estenne
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
L LandsR Gauthier
American Journal of Respiratory and Critical Care Medicine
J G PantojaM B Reid
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
G MauryT Troosters
© 2021 Meta ULC. All rights reserved