Preferential reduction of synaptic efficacy in the dentate gyrus of hippocampal slices from aged rats during reduced glucose availability

Neuroscience
R T JonesPeter R Patrylo

Abstract

Glutamatergic synaptic activity entails a high energetic cost. During aging, a variety of neural metabolic changes have been reported that could compromise the capacity of neural circuits to maintain synaptic transmission during periods of reduced extracellular glucose. Indeed, a preferential compromise in evoked synaptic activity has been observed in hippocampal CA1 with age during exposure to low-glucose solutions. Whether this aging-related compromise in synaptic activity is regionally specific is unclear, however. Data suggest that the dentate gyrus (DG) preferentially exhibits hypometabolism with age and this region plays a critical role in spatial pattern separation, which is compromised with age. Therefore, we assessed whether synaptic activity is also preferentially affected in the DG with age. In vitro extracellular field potential recordings were used to monitor orthodromic and antidromic evoked activity in the DG granule cell layer in hippocampal slices from adult (8-12 months) and aged (22-27 months) rats in aCSF containing 10mM glucose, followed by a reduced glucose aCSF containing 1mM glucose. In 10mM glucose-aCSF, orthodromic- and antidromic-evoked field potential activity was comparable between age groups. Howev...Continue Reading

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