PMID: 9652895Jul 4, 1998Paper

Preferential use of branched-chain amino acids as an energy substrate in patients with liver cirrhosis

Internal Medicine
M KatoHisataka Moriwaki

Abstract

We analyzed basal energy metabolism in 20 healthy volunteers and 41 cirrhotic patients by indirect calorimetry. Subjects were then given either glucose, branched-chain amino acids (BCAA) or fatty acids as an energy substrate. Resting energy expenditure (REE), nonprotein respiratory quotient (npRQ), and oxidation rates of glucose (% CHO), protein (% PRO) and fat (% FAT) were analyzed. REE and %FAT were significantly higher and % CHO and %PRO were significantly lower in cirrhosis than in controls. These changes correlated with disease severity. Glucose and BCAA were utilized efficiently as energy substrates and reduced %FAT in cirrhosis. Energy efficacy (increased energy expenditure/energy equivalent of the supplemented nutrient) was significantly higher in BCAA (96 +/- 16%) than in glucose (41 +/- 8%) (p<0.01) and fatty acids (27 +/- 13%) (p<0.05). Patients with cirrhosis have an increased energy requirement. BCAA seems to be the preferred substrate to meet this demand, because its energy efficacy is higher than glucose or fatty acids in cirrhosis.

Citations

Mar 8, 2002·Nutrition·Masahiro TajikaHisataka Moriwaki
Dec 7, 2011·Journal of Gastroenterology and Hepatology·Paolo SorrentinoSalvatore D' Angelo
Jan 1, 2010·Journal of Nutritional Science and Vitaminology·Yoichi TerakuraHisataka Moriwaki
Nov 28, 2013·World Journal of Gastroenterology : WJG·Kazuto Tajiri, Yukihiro Shimizu
Mar 25, 2014·World Journal of Gastroenterology : WJG·Nobuyuki ToshikuniMikihiro Tsutsumi
Feb 11, 2012·Clinics in Liver Disease·Pranav Periyalwar, Srinivasan Dasarathy
Jan 20, 2007·Nutrition·Yutaka NakayaUNKNOWN Hepatic Nutritional Therapy (HNT) Study Group
Jun 30, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Etsushi KawamuraSusumu Shiomi
Jul 24, 2008·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Keiko KorenagaIsao Sakaida
Mar 3, 2012·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Daisuke MoriharaShotaro Sakisaka
Feb 16, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Makoto ShirakiHisataka Moriwaki
Apr 23, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Tatsunori HanaiHisataka Moriwaki
Dec 20, 2003·Biochemical and Biophysical Research Communications·Hisataka MoriwakiMakoto Shiraki
Dec 3, 2014·Nutrition·Tatsunori HanaiHisataka Moriwaki
Jul 23, 2013·Nutrition·Carlos Moctezuma-VelázquezAldo Torre
Dec 1, 2012·Gastroenterology Research and Practice·Kenichiro YasutakeMunechika Enjoji
Jan 9, 2015·PLoS Neglected Tropical Diseases·Jeeyoun JungGeum-Sook Hwang
May 26, 2017·American Journal of Veterinary Research·John P LoftusTomasina A Lucia
Jun 2, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yohei UrataIsao Sakaida
Nov 13, 2015·European Journal of Gastroenterology & Hepatology·César Prieto-FríasJorge Quiroga
Jun 17, 2016·Medicine·Hiroki NishikawaShuhei Nishiguchi
Oct 9, 2019·Current Transplantation Reports·John Montgomery, Michael Englesbe
Oct 1, 2002·Clinical and Experimental Pharmacology & Physiology·Masahiko KatoHisataka Moriwaki
Feb 11, 2021·Nutrients·Julia TraubVanessa Stadlbauer
Jan 3, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Yurika KotohIsao Sakaida

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