PMID: 6407867Jun 27, 1983Paper

Preferential utilization of endogenous arachidonate by cyclo-oxygenase in incubations of human platelets

FEBS Letters
L SautebinR Paoletti

Abstract

Thromboxane B2 (TXB2) and 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) formed from the endogenous and exogenous arachidonate during human platelet incubation, was evaluated by selected ion monitoring (SIM). TXB2 formed from endogenous substrate accounted for about one third of the total, whereas the great part of 12-HETE derived from exogenous arachidonate. These data indicate that under the tested conditions the pool of arachidonate that acts as substrate for cyclo-oxygenase is different from the pool that acts as substrate for lipoxygenase and that the arachidonate released from phospholipids is preferentially utilized by cyclo-oxygenase.

References

Aug 28, 1979·Biochemical and Biophysical Research Communications·M I SiegelP Cuatrecasas
Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·S Hammarström, P Falardeau
Feb 20, 1975·Biochimica Et Biophysica Acta·D H Nugteren
Sep 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M Hamberg, B Samuelsson
Oct 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M HambergB Samuelsson

❮ Previous
Next ❯

Citations

Jan 1, 1988·Archives of Dermatological Research·E TragniC L Galli
Jan 1, 1986·The Journal of Membrane Biology·M C Sekar, L E Hokin
Jun 8, 2001·The Journal of Clinical Investigation·A R Brash
May 3, 2014·Journal of Pharmaceutical and Biomedical Analysis·Isabella SquellerioViviana Cavalca
Feb 1, 1992·Prostaglandins, Leukotrienes, and Essential Fatty Acids·D Duval, M Freyss-Beguin
Apr 1, 1986·Thrombosis Research·K D CroftR Vandongen
Apr 2, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Benedetta PorroViviana Cavalca
Feb 6, 2016·Annals of Dermatology·Semchin MunkhbayarOhsang Kwon
Feb 10, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Weronika AdachAdam Cieslak
Jul 1, 1991·Metabolism: Clinical and Experimental·H NumminenM Kaste

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.