Prefrontal alterations in GABAergic and glutamatergic gene expression in relation to depression and suicide

Journal of Psychiatric Research
J ZhaoDick F Swaab

Abstract

People that committed suicide were reported to have enhanced levels of gene transcripts for synaptic proteins in their prefrontal cortex (PFC). Given the close association of suicide with major depressive disorder (MDD), we here assessed whether these changes are related to suicide or rather to depression per se. We used quantitative PCR to determine mRNA levels of 32 genes encoding for proteins directly involved in glutamatergic or GABAergic synaptic transmission in postmortem samples of the anterior cingulate cortex (ACC) and the dorsolateral PFC (DLPFC). Seventy-two brain samples from 3 groups of subjects were derived from the Stanley Medical Research Institute (SMRI): i) patients with MDD who committed suicide (MDD-S), ii) MDD patients who died of non-suicidal causes (MDD-NS) and iii) age-matched, non-psychiatric control subjects. In the ACC, a significantly enhanced expression of genes related to glutamatergic or GABAergic synaptic transmission was found only in MDD-S patients, whereas in MDD-NS patients, decreased levels for these transcripts were found. Moreover, in the DLPFC, expression of these genes was decreased in MDD-S, relative to MDD-NS patients, whereas both groups showed increased expression compared to control...Continue Reading

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Citations

Dec 20, 2019·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Rachel D ReichmanVirginia L Willour
Feb 1, 2020·Current Topics in Medicinal Chemistry·Domenico De BerardisLaura Orsolini
Aug 21, 2020·Stress : the International Journal on the Biology of Stress·Nikolay N DygaloGalina T Shishkina
Dec 5, 2019·Frontiers in Cellular Neuroscience·Xin-Rui QiLing Shan
Nov 16, 2019·International Journal of Bipolar Disorders·Julia AlcaideJuan Nacher
Mar 13, 2019·European Archives of Psychiatry and Clinical Neuroscience·Marta KrzyżanowskaTomasz Gos
Mar 16, 2019·International Journal of Molecular Sciences·Shigeyuki Chaki, Kenichi Fukumoto
Sep 13, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yuta YoshinoYogesh Dwivedi
Feb 23, 2021·Frontiers in Psychiatry·Liam Anuj O'LearyNaguib Mechawar
Jun 23, 2019·Biological Psychiatry·Juan ZhaoDick F Swaab
Jul 13, 2021·Frontiers in Human Neuroscience·Mehmet Utku KucukerPaul E Croarkin

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