Prefrontal contributions to metacognition in perceptual decision making.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Stephen M FlemingRaymond J Dolan

Abstract

Neuroscience has made considerable progress in understanding the neural substrates supporting cognitive performance in a number of domains, including memory, perception, and decision making. In contrast, how the human brain generates metacognitive awareness of task performance remains unclear. Here, we address this question by asking participants to perform perceptual decisions while providing concurrent metacognitive reports during fMRI scanning. We show that activity in right rostrolateral prefrontal cortex (rlPFC) satisfies three constraints for a role in metacognitive aspects of decision-making. Right rlPFC showed greater activity during self-report compared to a matched control condition, activity in this region correlated with reported confidence, and the strength of the relationship between activity and confidence predicted metacognitive ability across individuals. In addition, functional connectivity between right rlPFC and both contralateral PFC and visual cortex increased during metacognitive reports. We discuss these findings in a theoretical framework where rlPFC re-represents object-level decision uncertainty to facilitate metacognitive report.

References

Nov 5, 1997·NeuroImage·K J FristonR J Dolan
Feb 15, 2001·Journal of Cognitive Neuroscience·R N HensonR J Dolan
Apr 17, 2001·NeuroImage·J L AnderssonK Friston
Aug 28, 2001·Journal of the American Medical Informatics Association : JAMIA·D C Van EssenC H Anderson
Nov 8, 2001·Consciousness and Cognition·C KunimotoH Pashler
Jan 28, 2004·Annual Review of Psychology·Timothy D Wilson, Elizabeth W Dunn
Feb 21, 2004·Nature Reviews. Neuroscience·Narender Ramnani, Adrian M Owen
Mar 6, 2004·Psychonomic Bulletin & Review·Susan J GalvinJohn Whitmore
Apr 22, 2004·Schizophrenia Research·Aaron T BeckDebbie M Warman
Oct 16, 2004·Science·K Richard RidderinkhofSander Nieuwenhuis
Apr 1, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Scott A HuettelGregory McCarthy
Jun 16, 2005·NeuroImage·John Ashburner, Karl J Friston
Sep 13, 2005·Neuropsychologia·Taylor W SchmitzSterling C Johnson
Nov 16, 2005·Nature Neuroscience·Yun-Ching KaoJohn D E Gabrieli
Dec 6, 2005·Neuropsychology Review·Jasmeet K Pannu, Alfred W Kaszniak
Jan 24, 2007·Nature Neuroscience·Navindra PersaudAlan Cowey
Nov 9, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hongkeun Kim, Roberto Cabeza
May 10, 2008·Nature Reviews. Neuroscience·Hauke R HeekerenLeslie G Ungerleider
Jul 22, 2008·Nature Reviews. Neuroscience·Roberto CabezaMorris Moscovitch
Aug 8, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Simon van GaalVictor A F Lamme
Oct 1, 2008·Journal of Cognitive Neuroscience·Elizabeth F ChuaReisa A Sperling
Jan 14, 2009·Neuroinformatics·Jan Gläscher
Nov 12, 2009·Brain : a Journal of Neurology·María RocaJohn Duncan
Dec 8, 2009·Nature Neuroscience·Satoshi TsujimotoSteven P Wise
Apr 2, 2010·Journal of Neurophysiology·Stephen M FlemingRaymond J Dolan
Apr 16, 2010·Journal of Neurophysiology·Andrea InsabatoGustavo Deco
Jul 10, 2010·NeuroImage·Edmund T RollsGustavo Deco
Jul 28, 2010·Psychological Review·Timothy J Pleskac, Jerome R Busemeyer
Aug 10, 2010·Schizophrenia Bulletin·Sally E RiggsAaron T Beck
Aug 28, 2010·Science·Bahador BahramiChris D Frith
Sep 18, 2010·Science·Stephen M FlemingGeraint Rees
Jan 25, 2011·Consciousness and Cognition·Chen SongGeraint Rees
Jun 17, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Jessica R Andrews-Hanna
Jul 19, 2011·NeuroImage·Mkael SymmondsRaymond J Dolan
Aug 16, 2011·Annual Review of Psychology·Chris D Frith, Uta Frith
Oct 7, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marie BudaJon S Simons
Nov 11, 2011·Consciousness and Cognition·Brian Maniscalco, Hakwan Lau
Apr 12, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Adam Kepecs, Zachary F Mainen
Apr 12, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Stephen M Fleming, Raymond J Dolan

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Citations

Jun 19, 2013·Neuropsychologia·Dana DeMasterSimona Ghetti
Dec 12, 2012·Nature Neuroscience·Benedetto De MartinoRaymond J Dolan
Jun 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Pablo BarttfeldMariano Sigman
Jun 6, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Micah G EdelsonTali Sharot
Jul 27, 2014·Cognitive Psychology·John R Anderson, Jon M Fincham
Aug 8, 2014·Brain : a Journal of Neurology·Stephen M FlemingKaren E Blackmon
Feb 21, 2014·Attention, Perception & Psychophysics·Julia D I MeuweseJohannes J Fahrenfort
Jan 19, 2016·Frontiers in Psychology·Ian Clark, Guillaume Dumas
Jan 23, 2016·Attention, Perception & Psychophysics·Brian ManiscalcoHakwan Lau
Jan 8, 2016·Annual Review of Pharmacology and Toxicology·Amy F T Arnsten, Min Wang
Aug 13, 2014·Cerebral Cortex·Martin N HebartJohn-Dylan Haynes
Sep 26, 2015·Cognition·Ana L Fernandez CruzKirsten G Volz
Oct 27, 2015·Frontiers in Human Neuroscience·Johannes HeeremanHauke R Heekeren
Oct 24, 2015·Attention, Perception & Psychophysics·Esther De LoofFilip Van Opstal
May 15, 2013·Human Brain Mapping·Hikaru TakeuchiRyuta Kawashima
Oct 11, 2015·Cognitive, Affective & Behavioral Neuroscience·George A BuzzellCraig G McDonald
May 28, 2014·NeuroImage·Raphael HilgenstockOtto W Witte
Aug 21, 2015·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Erick J PaulF Gregory Ashby
Jul 30, 2014·Consciousness and Cognition·Emma C PalmerStephen M Fleming
Apr 2, 2015·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Jarrod C HinesDayna R Touron
Nov 19, 2014·The Quarterly Journal of Experimental Psychology : QJEP·Sam J Gilbert
Nov 13, 2014·Journal of Cognitive Neuroscience·Martín GrazianoMariano Sigman
Oct 7, 2014·Consciousness and Cognition·Sébastien Massoni
Apr 22, 2014·NeuroImage·John R AndersonJon M Fincham
Oct 16, 2013·Trends in Cognitive Sciences·Jacqueline GottliebAdrien Baranes
Oct 10, 2013·Journal of Affective Disorders·Andre Goettems BastosClarissa Marceli Trentini
Oct 30, 2014·Frontiers in Neuroscience·Adrien F BaranesJacqueline Gottlieb
Sep 23, 2014·Cognitive, Affective & Behavioral Neuroscience·Aryn PykeJohn R Anderson
Oct 15, 2014·Journal of Cognitive Neuroscience·Benjamin BairdJonathan W Schooler
May 11, 2016·Proceedings of the National Academy of Sciences of the United States of America·Dobromir RahnevMark D'Esposito
May 18, 2016·Wiley Interdisciplinary Reviews. Cognitive Science·Mahiko Konishi, Jonathan Smallwood
Jul 23, 2016·Social Cognitive and Affective Neuroscience·Pascal MolenberghsPhilipp Kanske
Aug 25, 2016·Scientific Reports·Ana B ChicaPedro M Paz-Alonso
Oct 30, 2016·Social Cognitive and Affective Neuroscience·Ai KoizumiHakwan Lau
Sep 11, 2016·Trends in Cognitive Sciences·Ophelia DeroyUta Noppeney
Nov 2, 2016·Frontiers in Human Neuroscience·Peter J Snow
Nov 7, 2016·Brain and Cognition·Aaron SchurgerOlaf Blanke
Dec 3, 2016·NeuroImage·Stephen WhitmarshDaniel Lundqvist

❮ Previous
Next ❯

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