Prefrontal cortex activation during a cognitive reappraisal task is associated with real-life negative affect reactivity

PloS One
Jojanneke A BastiaansenAlbertine J Oldehinkel

Abstract

The neural substrate of cognitive reappraisal has been well-mapped. Individuals who successfully downregulate negative affect (NA) by reshaping their thoughts about a potentially emotional situation show augmented activity in the prefrontal cortex (PFC), with attenuated activity in the amygdala. We performed functional neuroimaging with experience sampling to determine whether individual differences in brain activation correspond to differences in real-life NA. While being scanned, 69 female students (aged 18-25 years) were asked to perform a cognitive reappraisal task. In addition, repeated assessments (5/day, 14 days) of affect and minor events in real-life were conducted. Individual t-maps were created for an instructed downregulation contrast (downregulate negative-attend negative) and an uninstructed regulation contrast (attend negative-attend neutral). Mean beta values were extracted from a priori defined regions of interest in the bilateral amygdala and PFC and were correlated with three daily life NA measures: baseline (mean) NA, NA variability, and NA reactivity to negative events. Only one out of twelve correlations for the amygdalae was nominally significant, which did not survive correction for multiple comparisons....Continue Reading

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Citations

Jan 11, 2021·Current Opinion in Psychology·Maurizio Sicorello, Christian Schmahl
Feb 18, 2021·Journal of Neuropsychology·Riadh OuerchefaniDidier Le Gall

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