Prefrontal cortex and striatal activation by feedback in Parkinson's disease

Brain Research
Martijn KeitzKlaus L Leenders

Abstract

Positive feedbacks reinforce goal-directed behavior and evoke pleasure. In Parkinson's disease (PD) the striatal dysfunction impairs motor performance, but also may lead to decreased positive feedback (reward) processing. This study investigates two types of positive feedback processing (monetary feedback and positive informative feedback), both compared to meaningless feedback, in PD patients and elderly healthy controls, using fMRI. In addition, positive informative feedback will be compared to monetary feedback to determine whether positive informative feedback is just as salient as monetary feedback. Healthy controls showed increased activation in the left putamen during the monetary feedback condition compared to both the positive informative and meaningless feedback condition, without an effect in the medial Prefrontal Cortex (mPFC). In contrast, PD patients showed increased activation in the left putamen during the meaningless feedback condition compared to both positive feedback conditions. In addition, PD patients showed increased activation of the mPFC during both positive feedback conditions. This suggests that when confronted with positive feedback, the mPFC compensates for the striatal deficit. In conclusion, stria...Continue Reading

References

Apr 1, 1997·Current Opinion in Neurobiology·W Schultz
Mar 24, 1997·Neuroreport·G ThutK L Leenders
Jun 23, 2000·Behavioural Brain Research·R de la Fuente-FernándezA J Stoessl
Dec 16, 2000·Neuroreport·G KünigW Schultz
Aug 11, 2001·Science·R de la Fuente-FernándezA J Stoessl
Apr 30, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David H ZaldAlain Dagher
May 25, 2004·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Samuel M McClureP Read Montague
Jul 3, 2004·Biological Psychiatry·Raúl de la Fuente-FernándezA Jon Stoessl
Oct 16, 2004·Science·K Richard RidderinkhofSander Nieuwenhuis
Nov 6, 2004·Science·Michael J FrankRandall C O'reilly
Nov 20, 2004·The Psychiatric Clinics of North America·Edward C Lauterbach
Jan 27, 2006·Annals of Neurology·Oury MonchiJulien Doyon
Jul 13, 2007·Brain : a Journal of Neurology·Björn H SchottEmrah Düzel
Jan 16, 2008·Journal of Psychiatric Research·Fumiko HoeftAllan L Reiss

❮ Previous
Next ❯

Citations

Oct 15, 2011·AJNR. American Journal of Neuroradiology·H CaoM Zhang
Mar 15, 2016·Frontiers in Human Neuroscience·Petra ZemankovaMartin Bares
Jan 15, 2014·Neurocase·David C Perry, Joel H Kramer
Jul 28, 2009·Neuroscience and Biobehavioral Reviews·Ruth J van HolstAnna E Goudriaan
Mar 8, 2018·Journal of Neural Transmission·Ana MarquesPierre-Olivier Fernagut
May 10, 2017·Frontiers in Neurology·Sara GarofaloGraham K Murray

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal ganglia in Parkinson's disease (MDS)

The basal ganglia is comprised of the neostriatum, the external and internal pallidal segments, the subthalamic nucleus, the substantia nigra pars reticulata, and the pars compacta of the substantia nigra. The basal ganglia circuitry is responsible for the correct execution of voluntary movements and is implicated in Parkinson's disease. Here is the latest research investigating the basal ganglia in Parkinson's disease.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.