Prefrontal cortex, caloric restriction and stress during aging: studies on dopamine and acetylcholine release, BDNF and working memory

Behavioural Brain Research
Alberto Del ArcoFrancisco Mora

Abstract

This study was designed to investigate whether long-term caloric restriction during the life span of the rat changes the effects of an acute mild stress on the release of dopamine and acetylcholine in the prefrontal cortex (PFC) and on working memory performance. Spontaneous motor activity was also monitored and levels of BDNF measured in the prefrontal cortex, amygdala and hippocampus. Male Wistar rats (3 months of age) were housed during 3, 12, 21 and 27 months (6, 15, 24 and 30 months of age at the end of housing) in caloric restriction (CR; 40% food intake restriction) or control conditions. After behavioural testing, animals were further subdivided into two other groups. In one of the groups BDNF protein levels were determined. In the other group rats were implanted with guide cannulas into the PFC to perform microdialysis experiments. In CR rats the release of dopamine produced by handling stress did not differ from the response found in control rats of 6, 15 and 24 months of age. The release of acetylcholine was not changed at the ages of 6 and 15 months but reduced at the age of 24 months. Stress did not change dopamine or acetylcholine release in CR and control rats of 30 months of age. BDNF levels were increased in th...Continue Reading

References

Sep 16, 1976·Nature·A M ThierryJ Glowinski
Jan 1, 1991·Journal of Biological Rhythms·R E Mistlberger
Jul 1, 1987·Neurobiology of Aging·W W BeattyR A Bierley
Jan 1, 1987·Journal of Gerontology·D K IngramR L Walford
Feb 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·B L MurphyR H Roth
Jul 5, 1996·Science·R S Sohal, R Weindruch
Jul 1, 1997·Physiology & Behavior·J L WeedD K Ingram
Apr 29, 1998·Archives of General Psychiatry·A F Arnsten, P S Goldman-Rakic
Jan 16, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·C WangD B Allison
Feb 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stacy A Castner, Patricia S Goldman-Rakic
Mar 5, 2005·Nature Neuroscience·Trevor W Robbins
Dec 13, 2005·Science·Danica ChenLeonard Guarente
Dec 24, 2005·Nature Reviews. Neuroscience·Sara N Burke, Carol A Barnes
Mar 23, 2006·Nature Reviews. Neuroscience·Mark P Mattson, Tim Magnus
Jul 17, 2007·Neuroscience Letters·Federica LocchiRoberto Rimondini
Apr 4, 2009·Journal of Neural Transmission·Gregorio SegoviaFrancisco Mora

❮ Previous
Next ❯

Citations

Sep 6, 2012·Psychology and Aging·Nichole R LighthallMara Mather
Jun 7, 2014·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Simon Lowes CollinsonTze-Pin Ng
Jun 12, 2014·Journal of Neuropathology and Experimental Neurology·Mariona JovéReinald Pamplona
Apr 11, 2012·Neuroscience and Biobehavioral Reviews·Meryem Alamy, Wail A Bengelloun
Aug 4, 2015·Behavioural Pharmacology·Maribel Olivares-NazarioLucía Martínez-Mota
Mar 16, 2013·Acta Psychiatrica Scandinavica·B P F RuttenM Wichers
Sep 17, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Bingjin LiRanji Cui
Jul 20, 2016·Neurobiology of Learning and Memory·Armando CardosoJosé P Andrade
Oct 30, 2016·Experimental Gerontology·Pedro A PereiraM Dulce Madeira
Aug 11, 2020·Journal of the Experimental Analysis of Behavior·Danielle N TappMatthew S McMurray
Aug 18, 2018·Molecular Neurobiology·Bruno Lima GiacobboErik F J de Vries
Jun 9, 2021·Expert Review of Proteomics·Mariona JovéReinald Pamplona

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.